Gene

mllt10

ID

ZDB-GENE-041114-176

Name

MLLT10 histone lysine methyltransferase DOT1L cofactor

Symbol

mllt10 Nomenclature History

Previous Names

id:ibd5120
wu:fe48f12
zgc:92208 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have histone binding activity and nucleosome binding activity. Involved in canonical Wnt signaling pathway; cellular homeostasis; and intestinal epithelial structure maintenance. Predicted to localize to nucleus. Is expressed in brain; hindbrain; intestine; and midbrain. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor).

Genome Resources

Note

None

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Mahmoudi et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mllt10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid	601626

Associated With mllt10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019786	Zinc finger, PHD-type, conserved site
Domain	IPR001965	Zinc finger, PHD-type
Domain	IPR019787	Zinc finger, PHD-finger
Domain	IPR034732	Extended PHD (ePHD) domain
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type

Domain Details Per Protein

Protein	Length	Extended PHD (ePHD) domain	Zinc finger, FYVE/PHD-type	Zinc finger, PHD-finger	Zinc finger, PHD-type	Zinc finger, PHD-type, conserved site	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A2R8RZV0 InterPro	1059
UniProtKB:A0A2R8QE63 InterPro	1051
UniProtKB:A0A286YAM6 InterPro	1089
UniProtKB:F8W2W1 InterPro	1078
UniProtKB:E7F6V1 InterPro	1022
UniProtKB:Q5U394 InterPro	352
UniProtKB:F8W451 InterPro	1133
UniProtKB:F1RE24 InterPro	352

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	mllt10-204 (1) Ensembl	4589 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	mllt10-206 (1) Ensembl	6768 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	mllt10-208 (1) Ensembl	5383 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mllt10-004 (1) Ensembl	834 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mllt10-005 (1) Ensembl	840 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mllt10-006 (1) Ensembl	784 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mllt10-007 (1) Ensembl	714 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mllt10-008 (1) Ensembl	711 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mllt10-009 (1) Ensembl	849 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Ensembl Gene Tree

Citations