ZFIN ID: ZDB-GENE-041114-176
Gene Name: MLLT10 histone lysine methyltransferase DOT1L cofactor
Gene Symbol: mllt10    Nomenclature History

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Previous Names: id:ibd5120, wu:fe48f12, zgc:92208 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity. Involved in canonical Wnt signaling pathway; cellular homeostasis; and intestinal epithelial structure maintenance. Is expressed in brain; hindbrain; intestine; and midbrain. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor).
Genome Resources: Alliance (1),  Gene:492342 (1),  Ensembl(GRCz11):ENSDARG00000045401 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92208]
  2 figures (2 images) from Kudoh et al., 2001 [ibd5120]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010007Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la010998Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014516Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028600Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mllt10 N/A 1
    MO2-mllt10 N/A 1
    MO3-mllt10 N/A 1
    DISEASE ASSOCIATED WITH mllt10 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance Leukemia, acute myeloid 601626
    DISEASE ASSOCIATED WITH mllt10 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process canonical Wnt signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mllt10-204 (1)    Ensembl 4589
    mllt10-206 (1)    Ensembl 6768
    mllt10-208 (1)    Ensembl 5383
    ncRNA mllt10-004 (1)    Ensembl 834
    mllt10-005 (1)    Ensembl 840
    mllt10-006 (1)    Ensembl 784
    mllt10-007 (1)    Ensembl 714
    mllt10-008 (1)    Ensembl 711
    mllt10-009 (1)    Ensembl 849
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mllt10 No data available
    MARKER RELATIONSHIPS
    mllt10 Contained in: [BAC] CH211-14G13 (1)
    mllt10 Encodes: [EST] fe48f12, ibd5120
    [cDNA] MGC:92208 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007308 (1) 2859 nt
    Genomic GenBank:CR376737 (1) 158366 nt
    Select Tool
    Polypeptide UniProtKB:F8W451 (1) 1133 aa
    Sequence Information (all 46)
    ORTHOLOGY for mllt10 ( Chr: 24 )
    CITATIONS (28)