Gene

mllt10

ID
ZDB-GENE-041114-176
Name
MLLT10 histone lysine methyltransferase DOT1L cofactor
Symbol
mllt10 Nomenclature History
Previous Names
  • id:ibd5120
  • wu:fe48f12
  • zgc:92208 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have histone binding activity and nucleosome binding activity. Involved in canonical Wnt signaling pathway; cellular homeostasis; and intestinal epithelial structure maintenance. Predicted to localize to nucleus. Is expressed in brain; hindbrain; intestine; and midbrain. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Mahmoudi et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mllt10 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance Leukemia, acute myeloid 601626
Associated With mllt10 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019786 Zinc finger, PHD-type, conserved site
Domain IPR001965 Zinc finger, PHD-type
Domain IPR019787 Zinc finger, PHD-finger
Domain IPR034732 Extended PHD (ePHD) domain
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Domain Details Per Protein
Protein Length Extended PHD (ePHD) domain Zinc finger, FYVE/PHD-type Zinc finger, PHD-finger Zinc finger, PHD-type Zinc finger, PHD-type, conserved site Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A2R8RZV0 1059
UniProtKB:A0A2R8QE63 1051
UniProtKB:A0A286YAM6 1089
UniProtKB:F8W2W1 1078
UniProtKB:E7F6V1 1022
UniProtKB:Q5U394 352
UniProtKB:F8W451 1133
UniProtKB:F1RE24 352
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations