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ZIRC
ZFIN ID: ZDB-GENE-041114-176
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Gene Name: MLLT10 histone lysine methyltransferase DOT1L cofactor
Gene Symbol: mllt10    Nomenclature History

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Previous Names: id:ibd5120, wu:fe48f12, zgc:92208 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity. Involved in canonical Wnt signaling pathway; cellular homeostasis; and intestinal epithelial structure maintenance. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Is expressed in brain; hindbrain; intestine; and midbrain. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor).
Genome Resources: Alliance (1),  Gene:492342 (1),  Ensembl(GRCz11):ENSDARG00000045401 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92208]
  2 figures (2 images) from Kudoh et al., 2001 [ibd5120]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010007Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la010998Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la014516Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la028600Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mllt10 N/A 1
    MO2-mllt10 N/A 1
    MO3-mllt10 N/A 1
    PHENOTYPE
    Data: 3 figures from Mahmoudi et al., 2010
    Observed in:
    DISEASE ASSOCIATED WITH mllt10 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance Leukemia, acute myeloid 601626
    DISEASE ASSOCIATED WITH mllt10 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process canonical Wnt signaling pathway (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001965 (1)
  • InterPro:IPR011011 (1)
  • InterPro:IPR013083 (1)
  • InterPro:IPR019786 (1)
  • InterPro:IPR019787 (1)
  • InterPro:IPR034732 (1)
  • PROSITE:PS01359 (1)
  • PROSITE:PS50016 (1)
  • PROSITE:PS51805 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mllt10-204 (1)    Ensembl 4589
    Select Tool
    mllt10-206 (1)    Ensembl 6768
    Select Tool
    mllt10-208 (1)    Ensembl 5383
    Select Tool
    ncRNA mllt10-004 (1)    Ensembl 834
    Select Tool
    mllt10-005 (1)    Ensembl 840
    Select Tool
    mllt10-006 (1)    Ensembl 784
    Select Tool
    mllt10-007 (1)    Ensembl 714
    Select Tool
    mllt10-008 (1)    Ensembl 711
    Select Tool
    mllt10-009 (1)    Ensembl 849
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mllt10 No data available
    MARKER RELATIONSHIPS
    mllt10 Contained in: [BAC] CH211-14G13 (1) (order this)
    mllt10 Encodes: [EST] fe48f12, ibd5120 (order this)
    [cDNA] MGC:92208 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007308 (1) 2859 bp
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    Genomic GenBank:CR376737 (1) 158366 bp
    Select Tool
    Polypeptide UniProtKB:F8W451 (1) 1133 aa
    Select Tool
    Sequence Clusters UniGene:105604 (1)
    Sequence Information (all 48)
    ORTHOLOGY for mllt10 ( Chr: 24 )
    CITATIONS (26)