ZFIN Gene: mllt10

ZFIN ID: ZDB-GENE-041114-176

ZFIN ID: ZDB-GENE-041114-176

Gene Name:

MLLT10 histone lysine methyltransferase DOT1L cofactor

Gene Symbol:

mllt10 Nomenclature History

Previous Names:

id:ibd5120, wu:fe48f12, zgc:92208 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 24 Mapping Details/Browsers

Description:

Predicted to have metal ion binding activity. Involved in canonical Wnt signaling pathway; cellular homeostasis; and intestinal epithelial structure maintenance. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Is expressed in brain; hindbrain; intestine; and midbrain. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor).

Genome Resources:

Alliance (1), Gene:492342 (1), Ensembl(GRCz11):ENSDARG00000045401 (2)

GENE EXPRESSION
All Expression Data:	5 figures from 4 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [MGC:92208]
	2 figures (2 images) from Kudoh et al., 2001 [ibd5120]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	brain hindbrain intestine midbrain whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la010007Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la010998Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la014516Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la028600Tg	Transgenic Insertion	Unknown	Unknown	DNA

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-mllt10	N/A	1
MO2-mllt10	N/A	1
MO3-mllt10	N/A	1

PHENOTYPE

Data:	3 figures from Mahmoudi et al., 2010
Observed in:	canonical Wnt signaling pathway epithelial cell intestinal epithelial structure maintenance intestinal epithelium intestinal villus intestine

DISEASE ASSOCIATED WITH mllt10 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid	601626

DISEASE ASSOCIATED WITH mllt10 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	canonical Wnt signaling pathway (more)
Molecular Function	metal ion binding (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	mllt10-204 (1)	4589	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mllt10-206 (1)	6768	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mllt10-208 (1)	5383	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mllt10-004 (1)	834	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mllt10-005 (1)	840	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mllt10-006 (1)	784	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mllt10-007 (1)	714	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mllt10-008 (1)	711	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mllt10-009 (1)	849	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM mllt10 No data available

MARKER RELATIONSHIPS

mllt10 Contained in:	[BAC] CH211-14G13 (1)
mllt10 Encodes:	[EST] fe48f12, ibd5120 [cDNA] MGC:92208 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001007308 (1)	2859 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR376737 (1)	158366 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F8W451 (1)	1133 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 46)

ORTHOLOGY for mllt10 ( Chr: 24 )

CITATIONS (27)

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