ZFIN ID: ZDB-GENE-041011-2
Gene Name: lin-7 homolog C (C. elegans)
Gene Symbol: lin7c    Nomenclature History

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Previous Names: fb75b09, wu:fb75b09, zgc:101881

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits L27 domain binding activity. Involved in maintenance of epithelial cell apical/basal polarity. Predicted to localize to MPP7-DLG1-LIN7 complex; basolateral plasma membrane; and synapse. Is expressed in several structures, including eye; neural rod; neural tube; neuroepithelial cell; and optic vesicle. Orthologous to human LIN7C (lin-7 homolog C, crumbs cell polarity complex component).
Genome Resources: Alliance (1),  Gene:447934 (1),  Ensembl(GRCz11):ENSDARG00000027322 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029330Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34103 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lin7c N/A 1
    MO2-lin7c N/A 1
    DISEASE ASSOCIATED WITH lin7c HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lin7c VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process maintenance of epithelial cell apical/basal polarity (more)
    Cellular Component cell junction (more)
    Molecular Function L27 domain binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lin7c-201 (1)    Ensembl 4301
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-lin7 polyclonal Rabbit IHC, WB 6
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lin7c No data available
    MARKER RELATIONSHIPS
    lin7c Contained in: [BAC] CH211-251J8 (1)
    lin7c Encodes: [EST] fb75b09 (1)
    [cDNA] MGC:101881 (1), MGC:192999 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004672 (1) 2453 nt
    Genomic GenBank:AL935207 (1) 146351 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QIA2 (1) 204 aa
    Sequence Information (all 20)
    ORTHOLOGY for lin7c ( Chr: 7 )
    CITATIONS (25)