ZFIN ID: ZDB-GENE-040718-178
Gene Name: NK6 homeobox 1
Gene Symbol: nkx6.1    Nomenclature History

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Previous Name: zgc:92879

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate commitment; enteroendocrine cell differentiation; and spinal cord motor neuron differentiation. Predicted to localize to nucleus. Is expressed in several structures, including DEL; endoderm; nervous system; neural tube; and pancreatic system. Orthologous to human NKX6-1 (NK6 homeobox 1).
Genome Resources: Alliance (1),  Gene:436748 (1),  Ensembl(GRCz11):ENSDARG00000022569 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3108 Point Mutation Unknown Splice Site ENU
ulg005 Small Deletion Unknown Frameshift, Premature Stop CRISPR
um321 Small Deletion Exon 1 Frameshift, Premature Stop CRISPR
um322 Indel Exon 1 Frameshift, Premature Stop CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-nkx6.1 1
CRISPR2-nkx6.1 1
MO1-nkx6.1 N/A 4
MO2-nkx6.1 N/A 1
DISEASE ASSOCIATED WITH nkx6.1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH nkx6.1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process endocrine pancreas development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nkx6.1-201 (1)    Ensembl 2023
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab2-nkx6 monoclonal IgG1 , k Mouse IHC, WB Developmental Studies Hybridoma Bank
15
Ab1-nkx6 polyclonal Rabbit IHC 3
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nkx6.1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
TgBAC(nkx6.1:EGFP) nkx6.1 EGFP Danio rerio 1 3
MARKER RELATIONSHIPS
nkx6.1 Contained in: [BAC] CH211-203L7 (1)
nkx6.1 Encodes: [cDNA] MGC:92879 (1), MGC:191271 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001002475 (1) 2045 nt
Genomic GenBank:BX000991 (1) 170966 nt
Select Tool
Polypeptide UniProtKB:F1QUC3 (1) 312 aa
Sequence Information (all 16)
ORTHOLOGY for nkx6.1 ( Chr: 21 )
CITATIONS (64)