Gene

nkx6.1

ID
ZDB-GENE-040718-178
Name
NK6 homeobox 1
Symbol
nkx6.1 Nomenclature History
Previous Names
  • zgc:92879
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate commitment; enteroendocrine cell differentiation; and spinal cord motor neuron differentiation. Predicted to localize to nucleus. Is expressed in several structures, including DEL; endoderm; nervous system; neural tube; and pancreatic system. Orthologous to human NKX6-1 (NK6 homeobox 1).
Genome Resources
Note
None
Expression
All Expression Data
41 figures from 28 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nkx6.1 Human Ortholog
No data available
Associated With nkx6.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR020479 Homeobox domain, metazoa
Family IPR033630 Homeobox protein NKX-6.1
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Helix-turn-helix motif Homeobox, conserved site Homeobox domain Homeobox domain, metazoa Homeobox-like domain superfamily Homeobox protein NKX-6.1
UniProtKB:Q5VJF4 312
UniProtKB:Q6DGK5 312
UniProtKB:F1QUC3 312
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-nkx6 monoclonal IgG1 , k Mouse
  • IHC
  • WB
Developmental Studies Hybridoma Bank
15
Ab1-nkx6 polyclonal Rabbit
  • IHC
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations