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ZIRC
ZFIN ID: ZDB-GENE-070626-1
Gene Name: NK6 homeobox 2
Gene Symbol: nkx6.2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in pancreatic A cell differentiation; spinal cord motor neuron differentiation; and type B pancreatic cell differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in spastic ataxia 8. Is expressed in several structures, including central nervous system; endoderm; neural plate; neuroectoderm; and pancreatic system. Orthologous to human NKX6-2 (NK6 homeobox 2).
Genome Resources: Alliance (1),  Gene:565782 (1),  Ensembl(GRCz11):ENSDARG00000104735 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018722Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa660 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nkx6.2 N/A 1
    MO2-nkx6.2 N/A 2
    MO3-nkx6.2 N/A 1
    MO4-nkx6.2 N/A 1
    DISEASE ASSOCIATED WITH nkx6.2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spastic ataxia 8 Alliance Spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy 617560
    DISEASE ASSOCIATED WITH nkx6.2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocrine pancreas development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-nkx6 polyclonal Rabbit IHC 3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nkx6.2 No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001135784 (1)
    Genomic GenBank:CABZ01085047 (1) 21940 bp
    Polypeptide UniProtKB:A3QRJ9 (1) 280 aa
    Sequence Clusters UniGene:15365 (1)
    Sequence Information (all 16)
    ORTHOLOGY for nkx6.2 ( Chr: 13 )
    CITATIONS (30)