ZFIN ID: ZDB-GENE-070626-1
Gene Name: NK6 homeobox 2
Gene Symbol: nkx6.2
Sequence Ontology ID : SO:0000704

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have sequence-specific DNA binding activity; involved in pancreatic A cell differentiation, spinal cord motor neuron differentiation, and type B pancreatic cell differentiation;  ...
GENE EXPRESSION
All Expression Data: 18 figures from 8 publications
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018722Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa660 Point Mutation Unknown Premature Stop ENU
    Targeting reagents:
    PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH nkx6.2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    spastic ataxia 8 Spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy 617560
    DISEASE ASSOCIATED WITH nkx6.2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocrine pancreas development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000047 (1)
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nkx6.2 No data available
    MARKER RELATIONSHIPSNo data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001135784 (1)
    Genomic GenBank:CABZ01085047 (1) 21940bp
    Polypeptide UniProtKB:A3QRJ9 (1) 280aa
    Sequence Clusters UniGene:15365 (1)
    Sequence Information (all 16)
    OTHER nkx6.2 GENE PAGES
  • Alliance (1)
  • Gene:565782 (1)
  • Ensembl(GRCz11):ENSDARG00000104735 (1)
  • ORTHOLOGY for nkx6.2 (Chr: 13)
    CITATIONS (29)