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ZIRC
ZFIN ID: ZDB-GENE-040707-1
Gene Name: iroquois homeobox 1a
Gene Symbol: irx1a    Nomenclature History

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Attributions

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Previous Names: ziro1a (1), zgc:109702, zgc:136490

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in central nervous system neuron differentiation; embryonic pectoral fin morphogenesis; and sensory organ development. Predicted to localize to the nucleus. Is expressed in several structures, including alar plate midbrain region; nervous system; neural plate; pericardial region; and pronephros. Orthologous to human IRX1 (iroquois homeobox 1).
Genome Resources: Alliance (1),  Gene:403019 (1),  Ensembl(GRCz11):ENSDARG00000101831 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa15451 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24999 Point Mutation Unknown Premature Stop ENU
    sa42638 Point Mutation Unknown Missense, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45558 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-irx1a N/A 1
    MO2-irx1a N/A 2
    MO3-irx1a N/A 3
    MO4-irx1a N/A 1
    DISEASE ASSOCIATED WITH irx1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH irx1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process nervous system development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 13)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA irx1a-201 (1)    Ensembl 1656
    irx1a-202 (1)    Ensembl 1730
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM irx1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg1(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-irx1a-LOXP-gata2a:EGFP-5HS4) gata2airx1a DsRedEGFP Danio rerioXenopus laevis 3 3
    Tg2(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-irx1a-LOXP-gata2a:EGFP-5HS4) gata2airx1a DsRedEGFP Danio rerioXenopus laevis 3 4
    MARKER RELATIONSHIPS
    irx1a Contained in: [BAC] CH73-211K12 (1) (order this)
    irx1a Contains: [SSLP] z9535 (1)
    irx1a Encodes: [cDNA] MGC:109702 (1) (order this), MGC:136490 (1) (order this), MGC:195323 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_207184 (1) 1764 bp
    Genomic GenBank:CU855690 (1) 67458 bp
    Select Tool
    Polypeptide UniProtKB:B3DKL9 (1) 426 aa
    Sequence Clusters UniGene:83685 (1)
    Sequence Information (all 30)
    ORTHOLOGY for irx1a ( Chr: 16 )
    CITATIONS (38)