Gene

irx1a

ID
ZDB-GENE-040707-1
Name
iroquois homeobox 1a
Symbol
irx1a Nomenclature History
Previous Names
  • ziro1a (1)
  • zgc:109702
  • zgc:136490
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in central nervous system neuron differentiation; embryonic pectoral fin morphogenesis; and sensory organ development. Predicted to localize to nucleus. Is expressed in several structures, including alar plate midbrain region; nervous system; neural plate; pericardial region; and pronephros. Orthologous to human IRX1 (iroquois homeobox 1).
Genome Resources
Note
None
Expression
All Expression Data
22 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irx1a Human Ortholog
No data available
Associated With irx1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003893 Iroquois-class homeodomain protein
Domain IPR008422 Homeobox KN domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox KN domain Homeobox-like domain superfamily Iroquois-class homeodomain protein
UniProtKB:B3DKL9 426
UniProtKB:A0A0R4ILR3 419
UniProtKB:Q568X8 148
UniProtKB:Q8JH33 419
UniProtKB:Q90XQ7 426
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations