ZFIN ID: ZDB-PUB-040514-10
Organization of Iroquois genes in fish
Dildrop, R., and Ruther, U.
Date: 2004
Source: Development genes and evolution   214(6): 267-276 (Journal)
Registered Authors:
Keywords: Irx genes, Gene cluster, Duplication, Cluster diversification
MeSH Terms:
  • Animals
  • Evolution, Molecular
  • Gene Duplication
  • Gene Expression
  • Genetic Linkage
  • Genome*
  • Homeodomain Proteins/genetics*
  • Multigene Family
  • Phylogeny
  • Takifugu/genetics*
  • Transcription Factors/genetics*
  • Zebrafish/genetics*
  • Zebrafish Proteins
PubMed: 15133664 Full text @ Dev. Genes Evol.
In mammals, a total of six iroquois ( Irx) genes exist, which are organized into two clusters. Here we report on the organization of all iroquois genes present in fish, using zebrafish ( Danio rerio) and pufferfish ( Fugu rubripes and Tetraodon nigroviridis) as examples. A total of 10 Irx genes were found in pufferfish, and 11 in zebrafish; all but one of these genes are organized into clusters (four clusters plus one isolated gene locus). The "extra" fish clusters result from chromosome duplication in the fish lineage, after its divergence from tetrapod vertebrates. Two of the four fish clusters are highly conserved to the ones in mammals, with regard to similarity of genes and cluster architecture. Irx genes within the other two clusters have diverged in sequence and cluster organization, suggesting functional divergence. These results will allow us to use the zebrafish system for functional and comparative studies of iroquois genes in vertebrate development.