ZFIN ID: ZDB-GENE-040426-57
Gene Name: structural maintenance of chromosomes 1A, like
Gene Symbol: smc1al
Sequence Ontology ID : SO:0000704

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Previous Names: smc1a (1), smc1l1 (1), im:7158706, SMC1 structural maintenance of chromosomes 1-like 1 (yeast), zgc:76902

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(Including Attributions)
Location: Chr: 23 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have ATP binding activity and chromatin binding activity; involved in embryonic viscerocranium morphogenesis; predicted to localize to the cohesin complex, integral component of  ...
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6906521]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7158706]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1113aTg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi2068Tg Transgenic Insertion Unknown Unknown DNA
    hi2327Tg Transgenic Insertion Unknown Unknown DNA
    hi3821Tg Transgenic Insertion Unknown Unknown DNA
    la014311Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014312Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11612 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18059 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24270 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32430 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37639 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 11 figures from 5 publications
    Observed in:
    DISEASE ASSOCIATED WITH smc1al HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Cornelia de Lange syndrome 2 300590
    DISEASE ASSOCIATED WITH smc1al VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Cornelia de Lange syndrome smc1alhi1113aTg/hi1113aTg standard conditions Cukrov et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic viscerocranium morphogenesis (more)
    Cellular Component chromosome (more)
    Molecular Function ATP binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003395 (1)
  • InterPro:IPR010935 (1)
  • InterPro:IPR024704 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR029683 (1)
  • InterPro:IPR036277 (1)
  • Pfam:PF02463 (1)
  • Pfam:PF06470 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA smc1al-001 (1) 4396
    smc1al-002 (1) 1750
    ncRNA smc1al-003 (1) 746
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM smc1al No data available
    MARKER RELATIONSHIPS
    smc1alContained in: [BAC] CH73-205F24 (1) (order this), DKEY-150I13 (1) (order this)
    smc1alEncodes: [EST] IMAGE:6906521 (1) (order this), IMAGE:7158706 (1) (order this)
    [cDNA] MGC:76902 (1) (order this)
    smc1alHas Artifact: [EST] fb40g11
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212810 (1) 1814bp
    Genomic GenBank:CR376802 (1) 73547bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QCL7 (1) 1251aa
    Sequence Clusters UniGene:76942 (1)
    Sequence Information (all 19)
    OTHER smc1al GENE PAGES
  • Alliance (1)
  • Gene:403060 (1)
  • VEGA:OTTDARG00000028117 (1)
  • Ensembl(GRCz11):ENSDARG00000058203 (2)
  • ORTHOLOGY for smc1al (Chr: 23)
    CITATIONS (34)