ZFIN ID: ZDB-GENE-040426-2500
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: ligand of numb-protein X 2b
Gene Symbol: lnx2b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: lnx-l (1), id:ibd3184, lnx-like (1), zgc:85925 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits ubiquitin-protein transferase activity. Involved in exocrine pancreas development and protein K48-linked ubiquitination. Is expressed in several structures, including blastodisc; mesoderm; nervous system; pronephros; and tail bud. Orthologous to human LNX2 (ligand of numb-protein X 2).
Genome Resources: Alliance (1),  Gene:564464 (1),  Ensembl(GRCz11):ENSDARG00000071478 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 5 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:85925]
  2 figures (3 images) from Kudoh et al., 2001 [ibd3184]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010014Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la012572Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la018980Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la018981Tg Transgenic Insertion Unknown Unknown DNA
    la027546Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lnx2b N/A 2
    MO2-lnx2b N/A 1
    MO3-lnx2b N/A 2
    MO4-lnx2b N/A 1
    PHENOTYPE
    Data: 3 figures from Ro et al., 2009
    Observed in:
    DISEASE ASSOCIATED WITH lnx2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lnx2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein K48-linked ubiquitination (more)
    Cellular Component cellular_component (more)
    Molecular Function ubiquitin-protein transferase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017907 Zinc finger, RING-type, conserved site
    Domain IPR001478 PDZ domain
    Domain IPR001841 Zinc finger, RING-type
    Domain IPR027370 RING-type zinc-finger, LisH dimerisation motif
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    Homologous_superfamily IPR036034 PDZ superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lnx2b-201 (1)    Ensembl 3150
    Select Tool
    lnx2b-202 (1)    Ensembl 572
    Select Tool
    ncRNA lnx2b-002 (1) 394
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS
    Addgene:666 pME-Lnx-1
    CONSTRUCTS WITH SEQUENCES FROM lnx2b No data available
    MARKER RELATIONSHIPS
    lnx2b Contained in: [BAC] CH211-231B5 (1), CH211-276G21 (1)
    lnx2b Encodes: [EST] ibd3184 (1)
    [cDNA] MGC:85925 (1), MGC:162185 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212940 (1) 3201 nt
    Select Tool
    Genomic GenBank:AL935131 170938 nt
    Select Tool
    Polypeptide UniProtKB:A4VCF7 (1) 678 aa
    Select Tool
    Sequence Information (all 24)
    ORTHOLOGY for lnx2b ( Chr: 14 )
    CITATIONS (31)