ZFIN ID: ZDB-GENE-040426-2500
Gene Name: ligand of numb-protein X 2b
Gene Symbol: lnx2b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: lnx-l (1), id:ibd3184, lnx-like (1), zgc:85925 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits ubiquitin-protein transferase activity. Involved in exocrine pancreas development and protein K48-linked ubiquitination. Is expressed in several structures, including blastodisc; mesoderm; nervous system; pronephros; and tail bud. Orthologous to human LNX2 (ligand of numb-protein X 2).
Genome Resources: Alliance (1),  Gene:564464 (1),  Ensembl(GRCz11):ENSDARG00000071478 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010014Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012572Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018980Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018981Tg Transgenic Insertion Unknown Unknown DNA
    la027546Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lnx2b N/A 2
    MO2-lnx2b N/A 1
    MO3-lnx2b N/A 2
    MO4-lnx2b N/A 1
    PHENOTYPE
    Data: 3 figures from Ro et al., 2009
    Observed in:
    DISEASE ASSOCIATED WITH lnx2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lnx2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein K48-linked ubiquitination (more)
    Cellular Component cellular_component (more)
    Molecular Function ubiquitin-protein transferase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017907 Zinc finger, RING-type, conserved site
    Domain IPR001478 PDZ domain
    Domain IPR001841 Zinc finger, RING-type
    Domain IPR027370 RING-type zinc-finger, LisH dimerisation motif
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    Homologous_superfamily IPR036034 PDZ superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lnx2b-201 (1)    Ensembl 3150
    lnx2b-202 (1)    Ensembl 572
    ncRNA lnx2b-002 (1) 394
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM lnx2b No data available
    MARKER RELATIONSHIPS
    lnx2b Contained in: [BAC] CH211-231B5 (1), CH211-276G21 (1)
    lnx2b Encodes: [EST] ibd3184 (1)
    [cDNA] MGC:85925 (1), MGC:162185 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212940 (1) 3201 nt
    Genomic GenBank:AL935131 170938 nt
    Select Tool
    Polypeptide UniProtKB:A4VCF7 (1) 678 aa
    Sequence Information (all 24)
    ORTHOLOGY for lnx2b ( Chr: 14 )
    CITATIONS (31)