ZFIN Gene: lnx2b

ZFIN ID: ZDB-GENE-040426-2500

ZFIN ID: ZDB-GENE-040426-2500

Gene Name:

ligand of numb-protein X 2b

Gene Symbol:

lnx2b

Sequence Ontology ID :

SO:0000704

Previous Names:

lnx-l (1), id:ibd3184, lnx-like (1), zgc:85925 (1)

Location:

Chr: 14 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Exhibits ubiquitin-protein transferase activity. Involved in exocrine pancreas development and protein K48-linked ubiquitination. Orthologous to human LNX2 (ligand of numb-protein X 2).

GENE EXPRESSION
All Expression Data:	6 figures from 5 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [MGC:85925]
	2 figures (3 images) from Kudoh et al., 2001 [ibd3184]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	anterior neural rod blastoderm blastodisc blastomere brain central nervous system dorsal aorta endoderm forebrain forerunner cell group Kupffer's vesicle lateral plate mesoderm liver notochord olfactory placode otic vesicle pharyngeal arch pharyngeal arch 3-7 skeleton pronephric duct pronephros segmental plate tail bud trunk neuron vascular cord whole organism anterior region whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la010014Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la012572Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la018980Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la018981Tg	Transgenic Insertion	Unknown	Unknown	DNA
la027546Tg	Transgenic Insertion	Unknown	Unknown	DNA

Targeting reagents:

PHENOTYPE

Data:	3 figures from Ro et al., 2009
Observed in:	whole organism

DISEASE ASSOCIATED WITH lnx2b HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH lnx2b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	protein K48-linked ubiquitination (more)
Cellular Component	cellular_component (more)
Molecular Function	ubiquitin-protein transferase activity (more)

GO Terms (all 8)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001478 (1) InterPro:IPR001841 (1) InterPro:IPR013083 (1) InterPro:IPR017907 (1) InterPro:IPR027370 (1) InterPro:IPR036034 (1)	PROSITE:PS00518 (1) PROSITE:PS50089 (1) PROSITE:PS50106 (1)	Pfam:PF00595 (1) Pfam:PF13445 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	lnx2b-002 (1)	394	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	lnx2b-201 (1)	3150	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	lnx2b-202 (1)	572	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Withdrawn Transcripts
ncRNA	lnx2b-004 (1)	810	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIESNo data available

PLASMIDS

Addgene

CONSTRUCTS WITH SEQUENCES FROM lnx2b No data available

MARKER RELATIONSHIPS

lnx2bContained in:	[BAC] CH211-231B5 (1) (order this), CH211-276G21 (1) (order this)
lnx2bEncodes:	[EST] ibd3184 (1) (order this) [cDNA] MGC:85925 (1) (order this), MGC:162185 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_212940 (1)	3201bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL935131	170938bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A4VCF7 (1)	678aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:30341 (1)

Sequence Information (all 25)

OTHER lnx2b GENE PAGES

Alliance (1)

Gene:564464 (1)

VEGA:OTTDARG00000024013 (1)

Ensembl(GRCz11):ENSDARG00000071478 (2)

ORTHOLOGY for lnx2b (Chr: 14)

CITATIONS (30)

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