Gene

sqstm1

ID
ZDB-GENE-040426-2204
Name
sequestosome 1
Symbol
sqstm1 Nomenclature History
Previous Names
  • p62 (1)
  • sb:cb621
  • zgc:85784 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have K63-linked polyubiquitin modification-dependent protein binding activity and protein kinase C binding activity. Involved in several processes, including axonogenesis; defense response to bacterium; and regulation of autophagy. Predicted to localize to aggresome and amphisome. Is expressed in several structures, including digestive system; epidermis; mesoderm; nervous system; and tail bud. Human ortholog(s) of this gene implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1).
Genome Resources
Note
None
Expression
All Expression Data
22 figures from 17 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sqstm1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
frontotemporal dementia and/or amyotrophic lateral sclerosis-3 Alliance Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 616437
GNE myopathy Alliance Myopathy, distal, with rimmed vacuoles 617158
Paget's disease of bone Alliance Paget disease of bone 3 167250
Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset 617145
Associated With sqstm1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000270 PB1 domain
Domain IPR000433 Zinc finger, ZZ-type
Domain IPR015940 Ubiquitin-associated domain
Domain IPR033741 Sequestosome-1, UBA domain
Domain IPR034866 Sequestosome-1, PB1 domain
Homologous_superfamily IPR009060 UBA-like superfamily
Homologous_superfamily IPR043145 Zinc finger, ZZ-type superfamily
Domain Details Per Protein
Protein Length PB1 domain Sequestosome-1, PB1 domain Sequestosome-1, UBA domain UBA-like superfamily Ubiquitin-associated domain Zinc finger, ZZ-type Zinc finger, ZZ-type superfamily
UniProtKB:Q6NWE4 357
UniProtKB:F1Q5Z8 452
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab4-sqstm1 polyclonal Rabbit
  • IHC
  • WB
MBL International
17
Ab10-sqstm1 polyclonal Rabbit
  • IHC
Enzo Life Sciences International, Inc.
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations