ZFIN ID: ZDB-GENE-040426-2204
Gene Name: sequestosome 1
Gene Symbol: sqstm1
Sequence Ontology ID : SO:0000704

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Previous Names: sb:cb621, zgc:85784 (1)

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 18 figures from 13 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb621]
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ibl52 Small Deletion Unknown Unknown CRISPR
Targeting reagents:
PHENOTYPE
Data: 4 figures from Lattante et al., 2015
Observed in:
DISEASE ASSOCIATED WITH sqstm1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
FTDALS3 Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 616437
Paget's disease of bone Paget disease of bone 3 167250
Myopathy, distal, with rimmed vacuoles 617158
Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset 617145
DISEASE ASSOCIATED WITH sqstm1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of autophagy (more)
Cellular Component aggresome (more)
Molecular Function metal ion binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000270 (1)
  • InterPro:IPR000433 (1)
  • InterPro:IPR009060 (1)
  • InterPro:IPR015940 (1)
  • InterPro:IPR033741 (1)
  • InterPro:IPR034866 (1)
  • PROSITE:PS01357 (1)
  • PROSITE:PS50030 (1)
  • PROSITE:PS50135 (1)
  • PROSITE:PS51745 (1)
  • Pfam:PF00564 (1)
  • Pfam:PF00569 (1)
  • Pfam:PF16577 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA sqstm1-001 (1) 1939
    ncRNA sqstm1-002 (1) 1832
    sqstm1-003 (1) 531
    sqstm1-004 (1) 1010
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM sqstm1 No data available
    MARKER RELATIONSHIPS
    sqstm1Contained in: [BAC] DKEY-177P5 (1) (order this)
    sqstm1Encodes: [EST] cb621 (1) (order this)
    [cDNA] MGC:85784 (1) (order this)
    sqstm1Is Hybridized by: [EST] fa95h08 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213173 (1) 1879bp
    Genomic GenBank:CU075768 (1) 161271bp
    Select Tool
    Polypeptide UniProtKB:F1Q5Z8 (1) 452aa
    Sequence Clusters UniGene:76246 (1)
    Sequence Information (all 18)
    OTHER sqstm1 GENE PAGES
  • Alliance (1)
  • Gene:406452 (1)
  • VEGA:OTTDARG00000027873 (1)
  • Ensembl(GRCz11):ENSDARG00000075014 (2)
  • ORTHOLOGY for sqstm1 (Chr: 14)
    CITATIONS (49)