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General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-2204
Gene Name: sequestosome 1
Gene Symbol: sqstm1
Sequence Ontology ID : SO:0000704

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Previous Names: p62 (1), sb:cb621, zgc:85784 (1)

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have K63-linked polyubiquitin modification-dependent protein binding activity and protein kinase C binding activity. Involved in axonogenesis; locomotory behavior; and regulation of  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ibl52 Small Deletion Unknown Unknown CRISPR
Targeting reagents:
DISEASE ASSOCIATED WITH sqstm1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
FTDALS3 Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 616437
Paget's disease of bone Paget disease of bone 3 167250
Myopathy, distal, with rimmed vacuoles 617158
Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset 617145
DISEASE ASSOCIATED WITH sqstm1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of autophagy (more)
Cellular Component aggresome (more)
Molecular Function metal ion binding (more)
GO Terms (all 17)
TRANSCRIPTS
Type Name Length (bp) Analysis
ncRNA sqstm1-002 (1) 1832
sqstm1-003 (1) 531
sqstm1-004 (1) 1010
mRNA sqstm1-202 (1) 1939
 Withdrawn Transcriptsextinct
GENE PRODUCT DESCRIPTION No description available
INTERACTIONS AND PATHWAYS
ANTIBODIES
PLASMIDSNo data available
CONSTRUCTS WITH SEQUENCES FROM sqstm1 No data available
MARKER RELATIONSHIPS
sqstm1Contained in: [BAC] DKEY-177P5 (1) (order this)
sqstm1Encodes: [EST] cb621 (1) (order this)
[cDNA] MGC:85784 (1) (order this)
sqstm1Is Hybridized by: [EST] fa95h08 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_213173 (1) 1879bp
Genomic GenBank:CU075768 (1) 161271bp
Select Tool
Polypeptide UniProtKB:F1Q5Z8 (1) 452aa
Sequence Clusters UniGene:76246 (1)
Sequence Information (all 18)
ORTHOLOGY for sqstm1 (Chr: 14)
CITATIONS (55)