ZFIN ID: ZDB-GENE-040426-2132
Gene Name: matrix metallopeptidase 9
Gene Symbol: mmp9    Nomenclature History

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Previous Names: fj05a08, gelatinase B (1), wu:fb02g06 (1), wu:fb07b05 (1), wu:fi98c09 (1), wu:fj05a08 (1), zgc:64165

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Involved in several processes, including collagen fibril organization; fin regeneration; and positive regulation of granuloma formation. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; female organism; head; hematopoietic cell; and hematopoietic system. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune hypersensitivity disease (multiple); and lung disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9).
Genome Resources: Alliance (1),  Gene:406397 (1),  Ensembl(GRCz11):ENSDARG00000042816 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el734 Small Deletion Unknown Unknown CRISPR
mi5003 Small Deletion Exon 2 Unknown CRISPR
mi5004 Insertion Exon 2 Unknown CRISPR
sa12776 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34399 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mmp9
    1
    CRISPR2-mmp9
    1
    CRISPR3-mmp9
    2
    CRISPR4-mmp9 1
    CRISPR5-mmp9 1
    MO1-mmp9 N/A 1
    MO2-mmp9 N/A 2
    MO3-mmp9 N/A 2
    MO4-mmp9 N/A 6
    MO5-mmp9 N/A 1
    MO6-mmp9 N/A 3
    MO7-mmp9 N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH mmp9 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Metaphyseal anadysplasia 2 613073
    DISEASE ASSOCIATED WITH mmp9 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to bacterium (more)
    Cellular Component extracellular matrix (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mmp9-201 (1)    Ensembl 2785
    ncRNA mmp9-002 (1)    Ensembl 583
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mmp9
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(mmp9:Cre-ERT2,cryaa:EGFP) cryaammp9 CreEGFPERT2 Danio rerio 1 1
    TgBAC(mmp9:EGFP) mmp9 EGFP Danio rerio 1 1
    TgBAC(mmp9:EGFP-NTR) mmp9 EGFPNTR Danio rerio 1 1
    MARKER RELATIONSHIPS
    mmp9 Contained in: [BAC] CH211-269M15 (1)
    mmp9 Contains: [SNP] rs3728152 (1), rs3728153 (1), rs3728154 (1)
    mmp9 Encodes: [EST] fb02g06 (1), fb07b05 (1), fi98c09 (1), fj05a08
    [cDNA] MGC:64165 (1), MGC:175074 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213123 (1) 2790 nt
    Genomic GenBank:CR391966 (1) 105854 nt
    Select Tool
    Polypeptide UniProtKB:F1QC76 (1) 680 aa
    Sequence Information (all 32)
    ORTHOLOGY for mmp9 ( Chr: 8 )
    CITATIONS (232)