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Gene

mmp9

ID
ZDB-GENE-040426-2132
Name
matrix metallopeptidase 9
Symbol
mmp9 Nomenclature History
Previous Names
  • fj05a08
  • gelatinase B (1)
  • wu:fb02g06 (1)
  • wu:fb07b05 (1)
  • wu:fi98c09 (1)
  • wu:fj05a08 (1)
  • zgc:64165
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable metalloendopeptidase activity. Acts upstream of or within several processes, including collagen fibril organization; fin regeneration; and positive regulation of granuloma formation. Predicted to be located in extracellular matrix and extracellular region. Is expressed in several structures, including cardiovascular system; female organism; head; hematopoietic cell; and hematopoietic system. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
120 figures from 84 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mmp9 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Metaphyseal anadysplasia 2 613073
Associated With mmp9 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021158 Peptidase M10A, cysteine switch, zinc binding site
Domain IPR000562 Fibronectin type II domain
Domain IPR000585 Hemopexin-like domain
Domain IPR001818 Peptidase M10, metallopeptidase
Domain IPR002477 Peptidoglycan binding-like
Domain IPR006026 Peptidase, metallopeptidase
Domain IPR033739 Peptidase M10A, catalytic domain
Family IPR021190 Peptidase M10A
Family IPR028688 Matrix metalloproteinase-9
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036365 PGBD-like superfamily
Homologous_superfamily IPR036366 PGBD superfamily
Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
Homologous_superfamily IPR036943 Fibronectin type II domain superfamily
Repeat IPR018487 Hemopexin-like repeats
Domain Details Per Protein
Protein Length Fibronectin type II domain Fibronectin type II domain superfamily Hemopexin-like domain Hemopexin-like domain superfamily Hemopexin-like repeats Kringle-like fold Matrix metalloproteinase-9 Metallopeptidase, catalytic domain superfamily Peptidase M10A Peptidase M10A, catalytic domain Peptidase M10A, cysteine switch, zinc binding site Peptidase M10, metallopeptidase Peptidase, metallopeptidase Peptidoglycan binding-like PGBD-like superfamily PGBD superfamily
UniProtKB:Q7T317 680
UniProtKB:F8QXP1 310
UniProtKB:F1QC76 680
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations