ZFIN Gene: uba1

ZFIN ID: ZDB-GENE-040426-2009

ZFIN ID: ZDB-GENE-040426-2009

Gene Name:

ubiquitin-like modifier activating enzyme 1

Gene Symbol:

uba1 Nomenclature History

Previous Names:

ube1 (1), fb30f01, wu:fa01e08, wu:fb30f01, wu:fi21c11, wu:fj14g11, zgc:66143

Gene Type:

protein_coding_gene

Location:

Chr: 23 Mapping Details/Browsers

Description:

Predicted to have ubiquitin activating enzyme activity. Involved in axonogenesis. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1).

Genome Resources:

Alliance (1), Gene:406335 (1), Ensembl(GRCz11):ENSDARG00000037559 (2)

GENE EXPRESSION
All Expression Data:	2 figures from 2 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [MGC:66143]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la011054Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa15137	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37679	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37680	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44999	Point Mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-uba1	N/A	1

PHENOTYPE

Data:	Fig. 3 from Wishart et al., 2014
Observed in:	motor neuron axon motor neuron collateral sprouting

DISEASE ASSOCIATED WITH uba1 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
X-linked spinal muscular atrophy 2	Alliance	Spinal muscular atrophy, X-linked 2, infantile	301830

DISEASE ASSOCIATED WITH uba1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	axonogenesis (more)
Cellular Component	cytoplasm (more)
Molecular Function	ATP binding (more)

GO Terms (all 13)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	uba1-201 (1)	4223	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	uba1-202 (1)	862	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	uba1-204 (1)	398	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	uba1-004 (1)	810	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM uba1 No data available

MARKER RELATIONSHIPS

uba1 Contained in:	[BAC] CH211-112C15 (1)
uba1 Encodes:	[EST] fa01e08 (1), fb30f01 (1), fi21c11 (1), fj14g11 (1) [cDNA] MGC:66143 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_213062 (1)	4156 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR339046 (1)	170974 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1RCA1 (1)	1058 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 23)

ORTHOLOGY for uba1 ( Chr: 23 )

CITATIONS (29)

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