ZFIN ID: ZDB-GENE-040426-2009
Gene Name: ubiquitin-like modifier activating enzyme 1
Gene Symbol: uba1    Nomenclature History

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Previous Names: ube1 (1), fb30f01, wu:fa01e08, wu:fb30f01, wu:fi21c11, wu:fj14g11, zgc:66143

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have ubiquitin activating enzyme activity. Involved in axonogenesis. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1).
Genome Resources: Alliance (1),  Gene:406335 (1),  Ensembl(GRCz11):ENSDARG00000037559 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66143]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011054Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15137 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37679 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37680 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44999 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-uba1 N/A 1
    DISEASE ASSOCIATED WITH uba1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    X-linked spinal muscular atrophy 2 Alliance Spinal muscular atrophy, X-linked 2, infantile 301830
    DISEASE ASSOCIATED WITH uba1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA uba1-201 (1)    Ensembl 4223
    uba1-202 (1)    Ensembl 862
    uba1-204 (1)    Ensembl 398
    ncRNA uba1-004 (1)    Ensembl 810
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM uba1 No data available
    MARKER RELATIONSHIPS
    uba1 Contained in: [BAC] CH211-112C15 (1)
    uba1 Encodes: [EST] fa01e08 (1), fb30f01 (1), fi21c11 (1), fj14g11 (1)
    [cDNA] MGC:66143 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213062 (1) 4156 nt
    Genomic GenBank:CR339046 (1) 170974 nt
    Select Tool
    Polypeptide UniProtKB:F1RCA1 (1) 1058 aa
    Sequence Information (all 23)
    ORTHOLOGY for uba1 ( Chr: 23 )
    CITATIONS (29)