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ZIRC
ZFIN ID: ZDB-GENE-040426-1740
Gene Name: fascin actin-bundling protein 2b, retinal
Gene Symbol: fscn2b    Nomenclature History

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Previous Names: fscn1l, fscn2, zgc:73272

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Predicted to be involved in actin filament bundle assembly; cell migration; and establishment or maintenance of cell polarity. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 30. Is expressed in eye; hair cell anterior macula; otic vesicle; retina; and retinal photoreceptor layer. Orthologous to human FSCN2 (fascin actin-bundling protein 2, retinal).
Genome Resources: Alliance (1),  Gene:393743 (1),  Ensembl(GRCz11):ENSDARG00000074396 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 3 publications
Directly Submitted Expression Data: 5 figures (7 images) from Thisse et al., 2004 [MGC:73272]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22154 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fscn2b N/A 1
    MO2-fscn2b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fscn2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    retinitis pigmentosa 30 Alliance Retinitis pigmentosa 30 607921
    DISEASE ASSOCIATED WITH fscn2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin cytoskeleton organization (more)
    Cellular Component cytoplasm (more)
    Molecular Function actin binding (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fscn2b-201 (1)    Ensembl 3389
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-fscn2 polyclonal Rabbit IHC, WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fscn2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(pvalb9:EGFP-fscn2b) pvalb9 EGFPfscn2b Danio rerio 1 2
    Tg(pvalb9:EGFP-fscn2b_S38A) pvalb9 EGFPfscn2b Danio rerio 1 1
    Tg(pvalb9:EGFP-fscn2b_S38E) pvalb9 EGFPfscn2b Danio rerio 1 1
    MARKER RELATIONSHIPS
    fscn2b Contained in: [BAC] CH73-218J1 (1) (order this), CH73-369D14 (1) (order this), DKEYP-92C5 (1)
    fscn2b Encodes: [cDNA] MGC:73272 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200770 (1) 1473 bp
    Genomic GenBank:CR932362 (1) 190415 bp
    Select Tool
    Polypeptide UniProtKB:B2LT50 (1) 490 aa
    Sequence Clusters UniGene:27145 (1)
    Sequence Information (all 16)
    ORTHOLOGY for fscn2b ( Chr: 12 )
    CITATIONS (25)