ZFIN ID: ZDB-GENE-031219-5
Gene Name: carbonic anhydrase II
Gene Symbol: ca2    Nomenclature History

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Previous Names: ca2a (1), cb1082 (1), wu:fb50f02, wu:fk91a02, zCA2-like a (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits carbonate dehydratase activity. Involved in several processes, including carbon dioxide transport; hypotonic salinity response; and sodium ion import across plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Is expressed in several structures, including gill; integument; nervous system; neural tube; and pleuroperitoneal region. Orthologous to several human genes including CA13 (carbonic anhydrase 13) and CA2 (carbonic anhydrase 2).
Genome Resources: Alliance (1),  Gene:387526 (1),  Ensembl(GRCz11):ENSDARG00000014488 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24527 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24528 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37925 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ca2 N/A 1
    MO2-ca2 N/A 2
    MO3-ca2 N/A 2
    DISEASE ASSOCIATED WITH ca2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive osteopetrosis 3 Alliance Osteopetrosis, autosomal recessive 3, with renal tubular acidosis 259730
    DISEASE ASSOCIATED WITH ca2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to xenobiotic stimulus (more)
    Molecular Function carbonate dehydratase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018338 Carbonic anhydrase, alpha-class, conserved site
    Domain IPR001148 Alpha carbonic anhydrase domain
    Family IPR023561 Carbonic anhydrase, alpha-class
    Homologous_superfamily IPR036398 Alpha carbonic anhydrase domain superfamily
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-ca2 polyclonal Rabbit IHC 2
    Ab1-ca2 polyclonal Rabbit IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ca2 No data available
    MARKER RELATIONSHIPS
    ca2 Contained in: [BAC] DKEY-158P1 (1) (order this)
    ca2 Contains: [SNP] rs3729333 (1)
    [STS] chunp30649
    ca2 Encodes: [EST] cb1082 (1) (order this), fb50f02
    [cDNA] MGC:63898 (1)
    ca2 Has Artifact: [EST] fk91a02
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199215 (1) 4330 nt
    Genomic GenBank:CR352287 (1) 153729 nt
    Select Tool
    Polypeptide UniProtKB:A0A385NIA3 (1) 260 aa
    Sequence Information (all 18)
    ORTHOLOGY for ca2 ( Chr: 24 )
    CITATIONS (49)