ZFIN ID: ZDB-GENE-030916-3
Gene Name: erb-b2 receptor tyrosine kinase 3a
Gene Symbol: erbb3a    Nomenclature History

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Previous Names: erbb3, im:7148890, si:dz150i12.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have neuregulin binding activity; neuregulin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including positive regulation of cell population proliferation; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Is expressed in epidermis; fin; glial cell; and heart. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000006202 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7148890]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la025736Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7024 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH erbb3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lethal congenital contracture syndrome 2 Alliance ?Lethal congenital contractural syndrome 2 607598
    {?Erythroleukemia, familial, susceptibility to} 133180
    DISEASE ASSOCIATED WITH erbb3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein phosphorylation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA erbb3a-001 (1) 3918
    erbb3a-203 (1)    Ensembl 6282
    erbb3a-204 (1)    Ensembl 412
    ncRNA erbb3a-002 (1) 532
    erbb3a-005 (1) 519
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM erbb3a No data available
    MARKER RELATIONSHIPS
    erbb3a Contained in: [BAC] CH73-354J22 (1), CH211-241A17 (1)
    [Fosmid] CH1073-215O18 (1)
    [PAC] BUSM1-150I12
    erbb3a Encodes: [EST] IMAGE:7148890 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA GenBank:CK686200 (1) 497 nt
    Genomic GenBank:AL953886 (1) 154152 nt
    Select Tool
    Polypeptide UniProtKB:F8W3W7 (1) 1319 aa
    Sequence Information (all 11)
    ORTHOLOGY for erbb3a ( Chr: 6 )
    CITATIONS (33)