Gene

erbb3a

ID
ZDB-GENE-030916-3
Name
erb-b2 receptor tyrosine kinase 3a
Symbol
erbb3a Nomenclature History
Previous Names
  • erbb3
  • im:7148890
  • si:dz150i12.1
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have neuregulin binding activity; neuregulin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including positive regulation of cell population proliferation; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Is expressed in epidermis; fin; glial cell; and heart. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With erbb3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lethal congenital contracture syndrome 2 Alliance ?Lethal congenital contractural syndrome 2 607598
{?Erythroleukemia, familial, susceptibility to} 133180
Associated With erbb3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000494 Receptor L-domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR006211 Furin-like cysteine-rich domain
Domain IPR032778 Growth factor receptor domain 4
Family IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036941 Receptor L-domain superfamily
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length Furin-like cysteine-rich domain Furin-like repeat Growth factor receptor cysteine-rich domain superfamily Growth factor receptor domain 4 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor L-domain Receptor L-domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine protein kinase, EGF/ERB/XmrK receptor
UniProtKB:F1QSK6 1305
UniProtKB:F8W2T0 138
UniProtKB:Q8AW81 1305
UniProtKB:F8W3W7 1319
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations