ZFIN Gene: cdh17

ZFIN ID: ZDB-GENE-030910-3

ZFIN ID: ZDB-GENE-030910-3

Gene Name:

cadherin 17, LI cadherin (liver-intestine)

Gene Symbol:

cdh17 Nomenclature History

Previous Names:

cb903 (1), fb65d02, wu:fb65d02 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 16 Mapping Details/Browsers

Description:

Predicted to have several functions, including cadherin binding activity; calcium ion binding activity; and protein homodimerization activity. Involved in pronephros development. Predicted to localize to the catenin complex; cell surface; and cell-cell adherens junction. Is expressed in intermediate cell mass of mesoderm; intermediate mesoderm; and renal system. Orthologous to human CDH17 (cadherin 17).

Genome Resources:

Alliance (1), Gene:378452 (1), Ensembl(GRCz11):ENSDARG00000005112 (2)

GENE EXPRESSION
All Expression Data:	68 figures from 39 publications
Directly Submitted Expression Data:	5 figures (5 images) from Thisse et al., 2001 [cb903]
Wild-type Stages, Structures:	Segmentation:5-9 somites (11.66h-14.0h) to Adult (90d-730d, breeding adult)
	intermediate cell mass of mesoderm intermediate mesoderm kidney developing mesonephric nephron kidney epithelial cell mesonephric nephron nephron progenitor posterior pronephric duct pronephric distal early tubule pronephric distal late tubule pronephric duct basolateral plasma membrane pronephric duct epithelial cell pronephric duct kidney epithelial cell pronephric duct pronephric proximal convoluted tubule pronephric proximal straight tubule pronephric tubule kidney epithelial cell pronephric tubule pronephros distal region pronephros proximal region pronephros renal tubule unspecified
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa11932	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa14279	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa32091	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa36153	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH cdh17 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH cdh17 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	pronephros development (more)
Cellular Component	integral component of membrane (more)
Molecular Function	calcium ion binding (more)

GO Terms (all 20)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR002126 (1) InterPro:IPR015919 (1) InterPro:IPR020894 (1) InterPro:IPR039808 (1)	PROSITE:PS00232 (1)	Pfam:PF00028 (1)

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	cdh17-201 (1)	3326	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cdh17-002 (1)	634	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab1-cdh17	polyclonal		Rabbit	IHC

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