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Gene

pak1

ID
ZDB-GENE-030826-29
Name
p21 protein (Cdc42/Rac)-activated kinase 1
Symbol
pak1 Nomenclature History
Previous Names
  • cb761 (1)
  • wu:fj97h10
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Enables identical protein binding activity and protein kinase activity. Acts upstream of with a positive effect on Wnt signaling pathway involved in dorsal/ventral axis specification and canonical Wnt signaling pathway. Acts upstream of or within animal organ development and convergent extension. Predicted to be active in cytoplasm. Is expressed in several structures, including axial mesoderm; cardiovascular system; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pak1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder with macrocephaly, seizures, and speech delay 618158
Associated With pak1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000095 CRIB domain
Domain IPR000719 Protein kinase domain
Domain IPR033923 p21 activated kinase binding domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036936 CRIB domain superfamily
Domain Details Per Protein
Protein Length CRIB domain CRIB domain superfamily p21 activated kinase binding domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q6P0I7 577
UniProtKB:A0A0R4IH73 579
UniProtKB:Q803Z0 577
UniProtKB:A0A0R4IC19 587
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pak Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations