ZFIN ID: ZDB-GENE-030826-29
Gene Name: p21 protein (Cdc42/Rac)-activated kinase 1
Gene Symbol: pak1    Nomenclature History

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Previous Names: cb761 (1), wu:fj97h10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Exhibits protein homodimerization activity and protein kinase activity. Involved in several processes, including animal organ development; convergent extension; and dorsal/ventral axis specification. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Is expressed in several structures, including axial mesoderm; cardiovascular system; nervous system; neural tube; and pectoral fin. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1).
Genome Resources: Alliance (1),  Gene:373103 (1),  Ensembl(GRCz11):ENSDARG00000103959 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pak1 N/A 4
MO2-pak1 N/A 2
DISEASE ASSOCIATED WITH pak1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder with macrocephaly, seizures, and speech delay 618158
DISEASE ASSOCIATED WITH pak1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process bulbus arteriosus development (more)
Cellular Component cytoplasm (more)
Molecular Function identical protein binding (more)
GO Terms (all 24)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000095 CRIB domain
Domain IPR000719 Protein kinase domain
Active_site IPR008271 Serine/threonine-protein kinase, active site
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR033923 p21 activated kinase binding domain
Homologous_superfamily IPR036936 CRIB domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pak1-001 (1) 1690
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-pak Rabbit IHC 2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pak1 No data available
MARKER RELATIONSHIPS
pak1 Contained in: [BAC] CH73-39G20 (1), CH73-293K19 (1), CH211-135H6 (1)
pak1 Encodes: [EST] cb761 (1) (order this), fj97h10 (1)
[cDNA] MGC:55281 (1), MGC:77309 (1), MGC:193033 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_201328 (1) 2811 bp
Genomic GenBank:CU459145 (1) 196166 bp
Select Tool
Polypeptide UniProtKB:A0A0R4IC19 (1) 587 aa
Sequence Information (all 34)
ORTHOLOGY for pak1 ( Chr: 18 )
CITATIONS (32)