ZFIN ID: ZDB-GENE-030131-3759
Gene Name: p21 protein (Cdc42/Rac)-activated kinase 2b
Gene Symbol: pak2b    Nomenclature History

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Previous Names: wu:fc52b03, zgc:113857

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in blood vessel development. Predicted to localize to cytoplasm. Is expressed in axial vasculature; endoderm; and nervous system. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2).
Genome Resources: Alliance (1),  Gene:325034 (1),  Ensembl(GRCz11):ENSDARG00000018476 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6898349]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pak2b N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH pak2b HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH pak2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process blood vessel development (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pak2b-201 (1)    Ensembl 2765
pak2b-202 (1)    Ensembl 975
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-pak Rabbit IHC 2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pak2b No data available
MARKER RELATIONSHIPS
pak2b Contained in: [BAC] CH73-159L23 (1)
pak2b Encodes: [EST] fc52b03, IMAGE:6898349 (1)
[cDNA] MGC:113857 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001025456 (1) 2786 nt
Genomic GenBank:CT027565 (1) 79954 nt
Select Tool
Polypeptide UniProtKB:Q4V9B9 (1) 539 aa
Sequence Information (all 22)
ORTHOLOGY for pak2b ( Chr: 22 )
CITATIONS (25)