ZFIN ID: ZDB-GENE-030822-1
Gene Name: tubulin, alpha 1b
Gene Symbol: tuba1b    Nomenclature History

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Previous Names: tuba1, cb944 (1), fb22g06, wu:fb22g06 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have GTP binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to localize to the cytoplasm and microtubule. Is expressed in several structures, including ectoderm; integument; nervous system; neural tube; and pleuroperitoneal region. Orthologous to several human genes including TUBA1C (tubulin alpha 1c).
Genome Resources: Alliance (1),  Gene:373080 (1),  Ensembl(GRCz11):ENSDARG00000045367 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12077 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa19333 Point Mutation Unknown Premature Stop ENU
    sa44030 Point Mutation Unknown Missense, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tuba1b N/A 1
    MO2-tuba1b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tuba1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tuba1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process microtubule-based process (more)
    Cellular Component cytoplasm (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017975 Tubulin, conserved site
    Domain IPR003008 Tubulin/FtsZ, GTPase domain
    Domain IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
    Family IPR000217 Tubulin
    Family IPR002452 Alpha tubulin
    Homologous_superfamily IPR008280 Tubulin/FtsZ, C-terminal
    Homologous_superfamily IPR023123 Tubulin, C-terminal
    Homologous_superfamily IPR036525 Tubulin/FtsZ, GTPase domain superfamily
    Homologous_superfamily IPR037103 Tubulin/FtsZ, C-terminal domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tuba1b-201 (1)    Ensembl 1588
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tuba1b No data available
    MARKER RELATIONSHIPS
    tuba1b Contained in: [BAC] DKEY-18F23 (1) (order this)
    tuba1b Encodes: [EST] cb944 (1) (order this), fb22g06 (1), fc11g01 (1) (order this), fc45a12 (1) (order this)
    [cDNA] MGC:173992 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_194388 (1) 1485 nt
    Genomic GenBank:BX465853 (1) 220945 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B8A516 (1) 449 aa
    Sequence Information (all 19)
    ORTHOLOGY for tuba1b ( Chr: 23 )
    CITATIONS (90)