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General Information
ZIRC
ZFIN ID: ZDB-GENE-030616-382
Gene Name: G protein-coupled receptor kinase 3
Gene Symbol: grk3    Nomenclature History

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Previous Names: GRK2/3 (1), adrbk2 (1), si:dz221d18.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits protein kinase activity. Involved in several processes, including heart rudiment formation; muscle cell development; and smoothened signaling pathway. Is expressed in several structures, including heart; immature eye; nervous system; notochord; and tail bud. Orthologous to several human genes including GRK3 (G protein-coupled receptor kinase 3).
Genome Resources: Alliance (1),  Gene:569403 (1),  Ensembl(GRCz11):ENSDARG00000104094 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
i283 Small Deletion Unknown Frameshift ZINC_FINGER_NUCLEASE
sa2558 Point Mutation Unknown Premature Stop ENU
sa2560 Point Mutation Unknown Premature Stop ENU
sa5588 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-grk3 N/A 6
MO2-grk3 N/A 1
MO3-grk3 N/A 1
DISEASE ASSOCIATED WITH grk3 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH grk3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process heart rudiment formation (more)
Molecular Function protein kinase activity (more)
GO Terms (all 16)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA adrbk2-001 (1) 1776
grk3-201 (1)    Ensembl 834
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
AB1-adrbk2 polyclonal Rabbit IHC, WB Santa Cruz Biotechnology, Inc.
3
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM grk3 No data available
MARKER RELATIONSHIPS
grk3 Contained in: [BAC] CH211-142E17 (1) (order this)
[PAC] BUSM1-221D18 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001134725 (1)
Genomic GenBank:FO704775 (1) 103561 bp
Select Tool
Polypeptide UniProtKB:A0A2R8QPB8 (1) 701 aa
Sequence Clusters UniGene:92943 (1)
Sequence Information (all 21)
ORTHOLOGY for grk3 ( Chr: 10 )
CITATIONS (26)