ZFIN Gene: nrp1a

ZFIN ID: ZDB-GENE-030519-2

ZFIN ID: ZDB-GENE-030519-2

Gene Name:

neuropilin 1a

Gene Symbol:

nrp1a Nomenclature History

Previous Names:

np-1, npn-1A (1), nrp1, znrp1, zgc:111785 (1), zgc:136674 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 24 Mapping Details/Browsers

Description:

Exhibits vascular endothelial growth factor-activated receptor activity. Involved in several processes, including animal organ development; circulatory system development; and generation of neurons. Predicted to localize to integral component of membrane. Is expressed in several structures, including blood vasculature; hematopoietic stem cell; hypochord; nervous system; and ventricular epicardium. Orthologous to human NRP1 (neuropilin 1).

Genome Resources:

Alliance (1), Gene:353246 (1), Ensembl(GRCz11):ENSDARG00000102153 (1)

GENE EXPRESSION
All Expression Data:	35 figures from 27 publications
Wild-type Stages, Structures:	Segmentation:5-9 somites (11.66h-14.0h) to Adult (90d-730d, breeding adult)
	blood vasculature common cardinal vein cranial neural crest cell diencephalon dorsal aorta dorsal habenular nucleus lateral region dorsal habenular nucleus left side dorsal habenular nucleus fin bud habenula head hematopoietic stem cell hypochord lateral plate mesoderm neural rod notochord olfactory receptor cell otic vesicle posterior cardinal vein primary motor neuron retinal ganglion cell layer spinal cord trunk motor neuron unspecified ventricular epicardium whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hu9963	Small Deletion	Unknown	Frameshift, Premature Stop	TALEN
hu10012	Small Deletion	Unknown	Frameshift, Premature Stop	TALEN
la028593Tg	Transgenic Insertion	Unknown	Unknown	DNA
sa32	Point Mutation	Unknown	Missense	ENU	European Zebrafish Resource Center (EZRC) (order this)
sa33	Point Mutation	Unknown	Unknown	ENU
sa34	Point Mutation	Unknown	Unknown	ENU
sa1485	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa24429	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24430	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37806	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-nrp1a		1
CRISPR2-nrp1a		1
CRISPR3-nrp1a		1
CRISPR4-nrp1a		1
MO1-nrp1a	N/A	4
MO2-nrp1a	N/A	21
MO3-nrp1a	N/A	1
MO4-nrp1a	N/A	1
MO5-nrp1a	N/A	1
MO6-nrp1a	N/A	1
MO7-nrp1a	N/A	1
MO8-nrp1a	N/A	2
MO9-nrp1a	N/A	1
MO10-nrp1a	N/A	1
TALEN1-nrp1a	hu10012 hu9963	2

PHENOTYPE

Data:

12 figures from 11 publications

Observed in:

DISEASE ASSOCIATED WITH nrp1a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH nrp1a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	response to hypoxia (more)
Cellular Component	integral component of membrane (more)
Molecular Function	vascular endothelial growth factor-activated receptor activity (more)

GO Terms (all 36)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	nrp1a-201 (1)	3875	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	nrp1a-202 (1)	3644	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	nrp1a-203 (1)	1977	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM nrp1a

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(14xUAS:nrp1a,GAP-Citrine)	UAS	Citrine, nrp1a	Danio rerio	1	2
Tg(nrp1a:GFP)	nrp1a	GFP	Danio rerio	2	11

MARKER RELATIONSHIPS

nrp1a Contained in:	[BAC] CH73-134F24 (1), DKEY-97G1 (1) (order this), DKEYP-9D12 (1), RP71-26B20 (1)
nrp1a Encodes:	[cDNA] MGC:111785, MGC:136674 (1), MGC:195315 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001040326 (1)	3901 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX323074 (1)	153860 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4IFP8 (1)	926 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 45)

ORTHOLOGY for nrp1a ( Chr: 24 )

CITATIONS (90)

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