ZFIN ID: ZDB-GENE-030519-2
Gene Name: neuropilin 1a
Gene Symbol: nrp1a    Nomenclature History

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Previous Names: np-1, npn-1A (1), nrp1, znrp1, zgc:111785 (1), zgc:136674 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits vascular endothelial growth factor-activated receptor activity. Involved in several processes, including animal organ development; circulatory system development; and generation of neurons. Predicted to localize to integral component of membrane. Is expressed in several structures, including blood vasculature; hematopoietic stem cell; hypochord; nervous system; and ventricular epicardium. Orthologous to human NRP1 (neuropilin 1).
Genome Resources: Alliance (1),  Gene:353246 (1),  Ensembl(GRCz11):ENSDARG00000102153 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu9963 Small Deletion Unknown Frameshift, Premature Stop TALEN
hu10012 Small Deletion Unknown Frameshift, Premature Stop TALEN
la028593Tg Transgenic Insertion Unknown Unknown DNA
sa32 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa33 Point Mutation Unknown Unknown ENU
    sa34 Point Mutation Unknown Unknown ENU
    sa1485 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24429 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24430 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37806 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nrp1a
    1
    CRISPR2-nrp1a
    1
    CRISPR3-nrp1a
    1
    CRISPR4-nrp1a
    1
    MO1-nrp1a N/A 4
    MO2-nrp1a N/A 21
    MO3-nrp1a N/A 1
    MO4-nrp1a N/A 1
    MO5-nrp1a N/A 1
    MO6-nrp1a N/A 1
    MO7-nrp1a N/A 1
    MO8-nrp1a N/A 2
    MO9-nrp1a N/A 1
    MO10-nrp1a N/A 1
    TALEN1-nrp1a 2
    DISEASE ASSOCIATED WITH nrp1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nrp1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to hypoxia (more)
    Cellular Component integral component of membrane (more)
    Molecular Function vascular endothelial growth factor-activated receptor activity (more)
    GO Terms (all 36)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nrp1a-201 (1)    Ensembl 3875
    nrp1a-202 (1)    Ensembl 3644
    nrp1a-203 (1)    Ensembl 1977
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nrp1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(14xUAS:nrp1a,GAP-Citrine) UAS Citrinenrp1a Danio rerio 1 2
    Tg(nrp1a:GFP) nrp1a GFP Danio rerio 2 11
    MARKER RELATIONSHIPS
    nrp1a Contained in: [BAC] CH73-134F24 (1), DKEY-97G1 (1) (order this), DKEYP-9D12 (1), RP71-26B20 (1)
    nrp1a Encodes: [cDNA] MGC:111785, MGC:136674 (1), MGC:195315 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040326 (1) 3901 nt
    Genomic GenBank:BX323074 (1) 153860 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IFP8 (1) 926 aa
    Sequence Information (all 45)
    ORTHOLOGY for nrp1a ( Chr: 24 )
    CITATIONS (90)