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Gene

nrp1a

ID
ZDB-GENE-030519-2
Name
neuropilin 1a
Symbol
nrp1a Nomenclature History
Previous Names
  • np-1
  • npn-1A (1)
  • nrp1
  • znrp1
  • zgc:111785 (1)
  • zgc:136674 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Enables vascular endothelial growth factor-activated receptor activity. Involved in several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of filopodium assembly; and vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within with a positive effect on angiogenesis involved in wound healing and cell activation. Acts upstream of or within several processes, including animal organ development; axon development; and circulatory system development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including blood vasculature; hematopoietic stem cell; hypochord; nervous system; and ventricular epicardium. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NRP1 (neuropilin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
35 figures from 27 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nrp1a Human Ortholog
No data available
Associated With nrp1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000421 Coagulation factor 5/8 C-terminal domain
Domain IPR000859 CUB domain
Domain IPR000998 MAM domain
Domain IPR022579 Neuropilin, C-terminal
Family IPR014648 Neuropilin
Family IPR027146 Neuropilin-1
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
Domain Details Per Protein
Protein Length Coagulation factor 5/8 C-terminal domain Concanavalin A-like lectin/glucanase domain superfamily CUB domain Galactose-binding-like domain superfamily MAM domain Neuropilin Neuropilin-1 Neuropilin, C-terminal Spermadhesin, CUB domain superfamily
UniProtKB:A0A0R4IFP8 926
UniProtKB:F1QXE5 923
UniProtKB:B3DKL1 916
UniProtKB:A0A0B5JK66 584
UniProtKB:Q8QFX6 923
UniProtKB:Q567N9 438
UniProtKB:A0A2R8RMW2 907
UniProtKB:Q69DB8 923
UniProtKB:A0A0R4IVS1 438
UniProtKB:Q1RLY9 916
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations