ZFIN ID: ZDB-GENE-030429-30
Gene Name: geminin DNA replication inhibitor
Gene Symbol: gmnn    Nomenclature History

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Previous Name: sb:cb254

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Involved in Kupffer's vesicle development; cilium assembly; and determination of left/right symmetry. Is expressed in several structures, including Kupffer's vesicle; immature eye; mesoderm; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 6. Orthologous to human GMNN (geminin DNA replication inhibitor).
Genome Resources: Alliance (1),  Gene:368320 (1),  Ensembl(GRCz11):ENSDARG00000035957 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-gmnn N/A 1
MO2-gmnn N/A 2
DISEASE ASSOCIATED WITH gmnn HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Meier-Gorlin syndrome 6 Alliance Meier-Gorlin syndrome 6 616835
DISEASE ASSOCIATED WITH gmnn VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cilium assembly (more)
Molecular Function protein binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
aberrant processed transcript gmnn-204 (1)    Ensembl 808
mRNA gmnn-201 (1)    Ensembl 1031
gmnn-202 (1)    Ensembl 786
ncRNA gmnn-004 (1)    Ensembl 818
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gmnn
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-3.5ubb:Cerulean-gmnn-2A-mCherry-cdt1) ubb 2Acdt1CeruleangmnnmCherry Danio rerio 2 7
Tg(-4.9sox10:mAGFP-gmnn-2A-mCherry-cdt1) sox10 2Acdt1gmnnmAGFPmCherry Danio rerio 1 1
Tg(EPV.Tp1-Mmu.Hbb:mAGFP-gmnn) gmnnmAGFP Danio rerioMus musculus 1 1
Tg(fabp10a:mAGFP-gmnn,cryaa:ECFP) cryaafabp10a ECFPgmnnmAGFP Danio rerio 1 4
Tg(fli1:mAGFP-gmnn) fli1 gmnnmAGFP Danio rerio 2 1
Tg(ins:mAGFP-gmnn,cryaa:mCherry) cryaains gmnnmAGFPmCherry Danio rerio 2 8
Tg(ins:mKOFP2-cdt1,ins:mAGFP-gmnn) ins cdt1gmnnmAGFPmKOFP2 Danio rerio 1 1
Tg(ins:Venus-gmnn,cryaa:Venus) cryaains gmnnVenus Danio rerio 1 2
Tg(kdrl:mVenus-gmnn) kdrl gmnnVenus Danio rerio 1 4
Tg(myl7:mVenus-gmnn) myl7 gmnnVenus Danio rerio 1 5
Tg(tcf21:mAGFP-gmnn) tcf21 gmnnmAGFP Danio rerio 1 3
Tg(UAS:NLS-mCherry,mVenus-gmnn) UAS gmnnmCherryNLSVenus Danio rerio 1 1
Tg(Xla.Eef1a1:gmnn-mCherry) gmnnmCherry Danio rerioXenopus laevis 1 4
Tg100(Xla.Eef1a1:mAGFP-gmnn) gmnnmAGFP Danio rerioXenopus laevis 9 17
Tg120(Xla.Eef1a1:mAGFP-gmnn) gmnnmAGFP Danio rerioXenopus laevis 2 2
MARKER RELATIONSHIPS
gmnn Contained in: [BAC] DKEY-218N20 (1) (order this)
gmnn Encodes: [EST] cb254 (1) (order this)
[cDNA] MGC:66217 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_200086 (1) 1106 nt
Genomic GenBank:BX957279 (1) 198752 nt
Select Tool
Polypeptide UniProtKB:Q1LU98 (1) 241 aa
Sequence Information (all 17)
ORTHOLOGY for gmnn ( Chr: 19 )
CITATIONS (72)