ZFIN ID: ZDB-GENE-030425-1
Gene Name: bridging integrator 1b
Gene Symbol: bin1b    Nomenclature History

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Previous Names: bin1, cb57 (1), zgc:86701

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have phospholipid binding activity and tau protein binding activity. Involved in cardiac muscle contraction. Predicted to localize to plasma membrane and synaptic vesicle. Is expressed in adaxial cell; cardiovascular system; musculature system; and somite. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to human BIN1 (bridging integrator 1).
Genome Resources: Alliance (1),  Gene:447863 (1),  Ensembl(GRCz11):ENSDARG00000058820 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2001 [cb57]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9213 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33802 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40630 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bin1b N/A 1
    DISEASE ASSOCIATED WITH bin1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    centronuclear myopathy 2 Alliance Centronuclear myopathy 2 255200
    DISEASE ASSOCIATED WITH bin1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardiac muscle contraction (more)
    Cellular Component cytoplasm (more)
    Molecular Function phospholipid binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bin1b-201 (1)    Ensembl 1878
    bin1b-202 (1)    Ensembl 867
    bin1b-203 (1)    Ensembl 756
    bin1b-204 (1)    Ensembl 777
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM bin1b No data available
    MARKER RELATIONSHIPS
    bin1b Contained in: [BAC] CH211-114N24 (1), CH211-237C6 (1)
    bin1b Encodes: [EST] cb57 (1)
    [cDNA] MGC:86701 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004602 (1) 1685 nt
    Genomic GenBank:CU659670 (1) 170331 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QMI5 (1) 576 aa
    Sequence Information (all 37)
    ORTHOLOGY for bin1b ( Chr: 6 )
    CITATIONS (21)