Gene

dio2

ID
ZDB-GENE-030327-4
Name
iodothyronine deiodinase 2
Symbol
dio2 Nomenclature History
Previous Names
  • D2 (1)
  • Deio2 (1)
  • cb684 (1)
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Exhibits thyroxine 5'-deiodinase activity. Involved in several processes, including chordate embryonic development; developmental pigmentation; and regulation of neural retina development. Predicted to localize to integral component of membrane. Is expressed in several structures, including digestive system; eye; hypophysis; male organism; and thyroid follicle. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2).
Genome Resources
Note
None
Expression
All Expression Data
24 figures from 18 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dio2 Human Ortholog
No data available
Associated With dio2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008261 Iodothyronine deiodinase, active site
Domain IPR013766 Thioredoxin domain
Family IPR000643 Iodothyronine deiodinase
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Domain Details Per Protein
Protein Length Iodothyronine deiodinase Iodothyronine deiodinase, active site Thioredoxin domain Thioredoxin-like superfamily
UniProtKB:Q7ZWK7 167
UniProtKB:Q6PBR8 257
UniProtKB:E9QGM3 258
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-dio2 polyclonal Rabbit
  • WB
1
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations