ZFIN ID: ZDB-GENE-030131-956
Gene Name: eukaryotic translation initiation factor 1
Gene Symbol: eif1    Nomenclature History

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Previous Names: eif1b (1), gc20 (1), wu:fb54a12, wu:fb64g08, wu:fk63g02, zgc:85781 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have ribosomal small subunit binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to localize to the eukaryotic 43S preinitiation complex. Orthologous to several human genes including EIF1B (eukaryotic translation initiation factor 1B).
Genome Resources: Alliance (1),  Gene:322237 (1),  Ensembl(GRCz11):ENSDARG00000012688 (2)
Note: In July 2019 it was determined that this gene, formerly known as eif1b, is actually an ortholog of mammalian EIF1 and the name was changed accordingly. Nomenclature changes can be confusing, so it is done only after compelling evidence is found to support the change. In this case, the evidence included strong AA identity, synteny and phylogenetic analysis. Another gene has been identifed as orthologous to the mammalian EIF1B.
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56459]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH eif1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH eif1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process translation (more)
Cellular Component eukaryotic 43S preinitiation complex (more)
Molecular Function translation initiation factor activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001950 SUI1 domain
Family IPR005874 Eukaryotic translation initiation factor SUI1
Homologous_superfamily IPR036877 SUI1 domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA eif1b-001 (1)    Ensembl 1336
ncRNA eif1b-002 (1)    Ensembl 773
eif1b-003 (1)    Ensembl 940
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM eif1 No data available
MARKER RELATIONSHIPS
eif1 Contained in: [BAC] DKEYP-113D7 (1)
eif1 Contains: [SNP] rs3728954 (1)
eif1 Encodes: [EST] fb54a12, fk63g02
[cDNA] MGC:56459 (1), MGC:85781 (1)
eif1 Has Artifact: [EST] fb64g08
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_199588 (1) 1297 nt
Genomic GenBank:BX323079 (1) 165200 nt
Select Tool
Polypeptide UniProtKB:Q7ZUI8 (1) 113 aa
Sequence Information (all 20)
ORTHOLOGY for eif1 ( Chr: 19 )
CITATIONS (33)