ZFIN ID: ZDB-GENE-030131-9433
Gene Name: pseudouridylate synthase 3
Gene Symbol: pus3    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: fj78b12, wu:fj78b12, zgc:56653 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human PUS3 (pseudouridine synthase 3).
Genome Resources: Alliance (1),  Gene:337487 (1),  Ensembl(GRCz11):ENSDARG00000028976 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56653]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hg26 Small Deletion Exon 2 Unknown CRISPR
hg27 Insertion Exon 2 Frameshift, Premature Stop CRISPR
hg28 Small Deletion Exon 7 Frameshift, Premature Stop CRISPR
sa32496 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pus3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pus3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pseudouridine synthesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function pseudouridine synthase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pus3-201 (1)    Ensembl 1860
    pus3-204 (1)    Ensembl 722
    ncRNA pus3-004 (1)    Ensembl 650
    pus3-005 (1)    Ensembl 854
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pus3 No data available
    MARKER RELATIONSHIPS
    pus3 Contained in: [BAC] CH211-40K21 (1), CH211-253B1 (1)
    pus3 Encodes: [EST] fj78b12
    [cDNA] MGC:56653 (1), MGC:86743 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200067 (1) 1712 nt
    Genomic GenBank:FP089511 (1) 158292 nt
    Select Tool
    Polypeptide UniProtKB:F1QBS4 (1) 460 aa
    Sequence Information (all 19)
    ORTHOLOGY for pus3 ( Chr: 24 )
    CITATIONS (20)