ZFIN ID: ZDB-GENE-030131-7450
Gene Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase a
Gene Symbol: tnksa    Nomenclature History

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Previous Names: TANK1 (1), tnks1a (1), tnks, wu:fj17h02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have NAD+ ADP-ribosyltransferase activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; positive regulation of telomere capping; and protein localization to chromosome, telomeric region. Predicted to localize to the cytoplasm and nucleus. Is expressed in brain; dorsal telencephalon; hypothalamus; medulla oblongata; and preoptic area. Orthologous to human TNKS (tankyrase).
Genome Resources: Alliance (1),  Gene:559022 (1),  Ensembl(GRCz11):ENSDARG00000077650 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8904 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16785 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18265 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25154 Point Mutation Unknown Splice Site ENU
    sa25155 Point Mutation Unknown Splice Site ENU
    sa37282 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tnksa N/A 1
    MO2-tnksa N/A 1
    PHENOTYPE
    Data: Fig. 7 from Wang et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH tnksa HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tnksa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of telomere maintenance via telomerase (more)
    Cellular Component cytoplasm (more)
    Molecular Function NAD+ ADP-ribosyltransferase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001660 Sterile alpha motif domain
    Domain IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
    Domain IPR020683 Ankyrin repeat-containing domain
    Family IPR028731 Poly [ADP-ribose] polymerase tankyrase-1
    Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
    Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
    Repeat IPR002110 Ankyrin repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tnksa-202 (1)    Ensembl 4394
    ncRNA tnksa-002 (1)    Ensembl 688
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tnks polyclonal Rabbit IHC Santa Cruz Biotechnology, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tnksa No data available
    MARKER RELATIONSHIPS
    tnksa Contained in: [BAC] DKEY-4K21 (1) (order this), DKEY-174F1 (1) (order this), DKEY-247M21 (1) (order this), DKEY-250J7 (1) (order this)
    tnksa Contains: [SNP] rs3729100 (1)
    tnksa Encodes: [EST] fj17h02
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_682318 (1) 6529 nt
    Genomic GenBank:CR848041 177962 nt
    Select Tool
    Polypeptide UniProtKB:E7FFW3 (1) 1280 aa
    Sequence Information (all 36)
    ORTHOLOGY for tnksa ( Chr: 21 )
    CITATIONS (20)