| ZFIN ID: ZDB-GENE-030131-4865 |
| Gene Name: | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b | |||||||||||||
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| Gene Symbol: | tnksb Nomenclature History |
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Attributions
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| Previous Names: | tnks1b (1), fe02c12, si:ch211-155m12.3, wu:fe02c12 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 5 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have NAD+ ADP-ribosyltransferase activity. Involved in glucose homeostasis. Predicted to localize to cytoplasm and nucleus. Is expressed in brain; liver; optic cup; pleuroperitoneal region; and retina. Orthologous to human TNKS (tankyrase). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:567533 (1), Ensembl(GRCz11):ENSDARG00000062897 (2) | |||||||||||||
| All Expression Data: | 2 figures from Wang et al., 2015 |
| Wild-type Stages, Structures: | Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult) |
| High Throughput Expression: | Expression Atlas (1) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa6961 | Point Mutation | Unknown | Premature Stop | ENU | |
| sa13277 | Point Mutation | Unknown | Premature Stop | ENU |
|
| sa40363 | Point Mutation | Unknown | Splice Site | ENU |
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PHENOTYPE
| Data: | 4 figures from Wang et al., 2015 |
| Observed in: |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | glucose homeostasis (more) |
| Cellular Component | cytoplasm (more) |
| Molecular Function | NAD+ ADP-ribosyltransferase activity (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
tnksb-201
(1)
|
4216 |
Select Tool
|
| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
| Name | Type | Isotype | Host Organism | Assay | Source | Publications |
|---|---|---|---|---|---|---|
| Ab1-tnks | polyclonal | Rabbit | IHC |
Santa Cruz Biotechnology, Inc.
|
2 |
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM tnksb
No data available
MARKER RELATIONSHIPS
| tnksb Contained in: | [BAC] CH211-155M12 (1) |
| tnksb Encodes: |
[EST]
fe02c12
[cDNA] MGC:193847 (1), MGC:193858 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001089415 (1) | 3961 nt |
Select Tool
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| Genomic | GenBank:AL928901 (1) | 145957 nt | |
| Polypeptide | UniProtKB:A0A0R4IYN3 (1) | 1274 aa |
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ORTHOLOGY for tnksb (
Chr:
5
)
CITATIONS (17)