ZFIN ID: ZDB-GENE-030131-4865
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Gene Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b
Gene Symbol: tnksb    Nomenclature History

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Previous Names: tnks1b (1), fe02c12, si:ch211-155m12.3, wu:fe02c12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have NAD+ ADP-ribosyltransferase activity. Involved in glucose homeostasis. Predicted to localize to the cytoplasm and nucleus. Is expressed in brain; liver; optic cup; pleuroperitoneal region; and retina. Orthologous to human TNKS (tankyrase).
Genome Resources: Alliance (1),  Gene:567533 (1),  Ensembl(GRCz11):ENSDARG00000062897 (2)
GENE EXPRESSION
All Expression Data: 2 figures from Wang et al., 2015
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6961 Point Mutation Unknown Premature Stop ENU
sa13277 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa40363 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tnksb N/A 1
    MO2-tnksb N/A 1
    PHENOTYPE
    Data: 4 figures from Wang et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH tnksb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tnksb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process glucose homeostasis (more)
    Cellular Component cytoplasm (more)
    Molecular Function NAD+ ADP-ribosyltransferase activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001660 Sterile alpha motif domain
    Domain IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
    Domain IPR020683 Ankyrin repeat-containing domain
    Family IPR028731 Poly [ADP-ribose] polymerase tankyrase-1
    Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
    Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
    Repeat IPR002110 Ankyrin repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tnksb-201 (1)    Ensembl 4216
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tnks polyclonal Rabbit IHC Santa Cruz Biotechnology, Inc.
    		2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tnksb No data available
    MARKER RELATIONSHIPS
    tnksb Contained in: [BAC] CH211-155M12 (1)
    tnksb Encodes: [EST] fe02c12
    [cDNA] MGC:193847 (1), MGC:193858 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001089415 (1) 3961 nt
    Select Tool
    Genomic GenBank:AL928901 (1) 145957 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IYN3 (1) 1274 aa
    Select Tool
    Sequence Information (all 22)
    ORTHOLOGY for tnksb ( Chr: 5 )
    CITATIONS (17)