ZFIN ID: ZDB-GENE-030131-7190
Gene Name: methyl CpG binding protein 2
Gene Symbol: mecp2    Nomenclature History

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Previous Names: wu:fk96a04, zgc:111857

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity. Involved in several processes, including nervous system development; neuromuscular junction development; and sensory perception of touch. Predicted to localize to chromatin and nucleus. Used to study Rett syndrome. Human ortholog(s) of this gene implicated in Rett syndrome; X-linked intellectual disability-psychosis-macroorchidism syndrome; autistic disorder; and syndromic X-linked intellectual disability Lubs type. Is expressed in several structures, including heart; kidney; muscle; nervous system; and skeletal system. Orthologous to human MECP2 (methyl-CpG binding protein 2).
Genome Resources: Alliance (1),  Gene:335250 (1),  Ensembl(GRCz11):ENSDARG00000014218 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh232 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026687Tg Transgenic Insertion Unknown Unknown DNA
    mecp2_unrecovered Point Mutation Unknown Unknown ENU
    sa21196 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mecp2
    1
    MO1-mecp2 N/A 1
    MO2-mecp2 N/A 2
    MO3-mecp2 N/A 1
    MO4-mecp2 N/A 1
    MO5-mecp2 N/A 1
    DISEASE ASSOCIATED WITH mecp2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Rett syndrome Alliance Rett syndrome 312750
    Rett syndrome, atypical 312750
    Rett syndrome, preserved speech variant 312750
    syndromic X-linked intellectual disability Lubs type Alliance Mental retardation, X-linked syndromic, Lubs type 300260
    X-linked intellectual disability-psychosis-macroorchidism syndrome Alliance Mental retardation, X-linked, syndromic 13 300055
    Encephalopathy, neonatal severe 300673
    {Autism susceptibility, X-linked 3} 300496
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis involved in innervation (more)
    Cellular Component host cell nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mecp2-201 (1)    Ensembl 1684
    mecp2-202 (1)    Ensembl 1673
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mecp2 polyclonal Rabbit IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mecp2 No data available
    MARKER RELATIONSHIPS
    mecp2 Contained in: [BAC] CH211-192F24 (1), DKEYP-77F7 (1)
    mecp2 Encodes: [EST] fk96a04
    [cDNA] MGC:111857 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212736 (1) 1673 nt
    Genomic GenBank:BX571687 (1) 173448 nt
    Select Tool
    Polypeptide UniProtKB:Q7T2T7 (1) 524 aa
    Sequence Information (all 17)
    ORTHOLOGY for mecp2 ( Chr: 8 )
    CITATIONS (48)