Gene

unc45b

ID

ZDB-GENE-020919-3

Name

unc-45 myosin chaperone B

Symbol

unc45b Nomenclature History

Previous Names

unc45r (1)
cb393 (1)
fb37f02
wu:fa05a03 (1)
wu:fa10f03
wu:fb37f02
wu:fb96f06
wu:fc10f04 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have Hsp90 protein binding activity. Involved in lens development in camera-type eye; striated muscle cell development; and striated muscle tissue development. Localizes to Z disc. Human ortholog(s) of this gene implicated in cataract 43. Is expressed in several structures, including cardiovascular system; eye; mesoderm; musculature system; and myoblast. Orthologous to human UNC45B (unc-45 myosin chaperone B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

32 figures from 17 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb393 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 26 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With unc45b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cataract 43	Alliance	?Cataract 43	616279
myofibrillar myopathy 11	Alliance	Myofibrillar myopathy 11	619178

Associated With unc45b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024660	UNC-45/Cro1/She4, central domain
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Repeat	IPR000225	Armadillo
Repeat	IPR019734	Tetratricopeptide repeat

Domain Details Per Protein

Protein	Length	Armadillo	Armadillo-like helical	Armadillo-type fold	Tetratricopeptide-like helical domain superfamily	Tetratricopeptide repeat	UNC-45/Cro1/She4, central domain
UniProtKB:Q6DGE9 InterPro	934

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	unc45b-202 (1) Ensembl	Havana	521 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	unc45b-201 (1) Ensembl	Havana	3821 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-unc45b	polyclonal	unc45b		Rabbit	IHC		1
Ab2-unc45b	polyclonal	unc45b		Guinea pig	IHC		2

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations