ZFIN ID: ZDB-GENE-020220-1
Gene Name: amyloid beta (A4) precursor protein b
Gene Symbol: appb
Sequence Ontology ID : SO:0000704

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Previous Names: wu:fc43a03 (1), zgc:92771

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(Including Attributions)
Location: Chr: 9 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
GENE EXPRESSION
All Expression Data: 15 figures from 6 publications
Directly Submitted Expression Data: 7 figures (15 images) from Thisse et al., 2004 [MGC:92771]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016566Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029590Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa327 Point Mutation Unknown Premature Stop ENU
    sa34693 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41475 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 22 figures from 6 publications
    Observed in:
    DISEASE ASSOCIATED WITH appb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Alzheimer's disease 1 Alzheimer disease 1, familial 104300
    APP-related cerebral amyloid angiopathy Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic variants 605714
    DISEASE ASSOCIATED WITH appb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002223 (1)
  • InterPro:IPR008154 (1)
  • InterPro:IPR008155 (1)
  • InterPro:IPR011178 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR013803 (1)
  • InterPro:IPR015849 (1)
  • InterPro:IPR019543 (1)
  • InterPro:IPR019744 (1)
  • InterPro:IPR019745 (1)
  • InterPro:IPR020901 (1)
  • InterPro:IPR024329 (1)
  • InterPro:IPR028866 (1)
  • InterPro:IPR036176 (1)
  • InterPro:IPR036454 (1)
  • InterPro:IPR036669 (1)
  • InterPro:IPR036880 (1)
  • InterPro:IPR037071 (1)
  • PROSITE:PS00280 (1)
  • PROSITE:PS00319 (1)
  • PROSITE:PS00320 (1)
  • PROSITE:PS50279 (1)
  • Pfam:PF00014 (1)
  • Pfam:PF02177 (1)
  • Pfam:PF03494 (1)
  • Pfam:PF10515 (1)
  • Pfam:PF12924 (1)
  • Pfam:PF12925 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA appb-001 (1) 4099
    appb-002 (1) 2256
    ncRNA appb-003 (1) 1531
    antisense ottdart00000059675 (1) 2776
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM appb
    MARKER RELATIONSHIPS
    appbContained in: [BAC] DKEY-192G7 (1) (order this)
    appbEncodes: [EST] fc43a03 (1)
    [cDNA] MGC:92771 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152886 (1) 4066bp
    Genomic GenBank:CR759841 (1) 94752bp
    Select Tool
    Polypeptide UniProtKB:B0V0E5 (1) 751aa
    Sequence Clusters UniGene:2615 (1)
    Sequence Information (all 34)
    OTHER appb GENE PAGES
  • Alliance (1)
  • Gene:170846 (1)
  • VEGA:OTTDARG00000025772 (1)
  • VEGA:OTTDARG00000041384 (1)
  • ORTHOLOGY for appb (Chr: 9)
    CITATIONS (48)