ZFIN ID: ZDB-GENE-020220-1
Gene Name: amyloid beta (A4) precursor protein b
Gene Symbol: appb    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: wu:fc43a03 (1), zgc:92771

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have heparin binding activity; serine-type endopeptidase inhibitor activity; and transition metal ion binding activity. Involved in several processes, including convergent extension; nervous system development; and regulation of Notch signaling pathway. Predicted to localize to integral component of membrane. Is expressed in several structures, including axial vasculature; axis; nervous system; notochord; and pronephric duct. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein).
Genome Resources: Alliance (1),  Gene:170846 (1),  Ensembl(GRCz11):ENSDARG00000055543 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016566Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029590Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa327 Point Mutation Unknown Premature Stop ENU
    sa34693 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41475 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-appb N/A 3
    MO2-appb N/A 2
    MO3-appb N/A 1
    MO4-appb N/A 1
    MO5-appb N/A 2
    DISEASE ASSOCIATED WITH appb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Alzheimer's disease 1 Alliance Alzheimer disease 1, familial 104300
    APP-related cerebral amyloid angiopathy Alliance Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic variants 605714
    DISEASE ASSOCIATED WITH appb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA appb-203 (1)    Ensembl 2256
    appb-205 (1)    Ensembl 4099
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-app monoclonal IgG1 Mouse WB Millipore
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM appb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(appb:EGFP) appb EGFP Danio rerio 1 4
    Tg1BAC(appb:EGFP) appb EGFP Danio rerio 1 2
    Tg2BAC(appb:EGFP) appb EGFP Danio rerio 1 2
    Tg3BAC(appb:EGFP) appb EGFP Danio rerio 2 2
    Tg4BAC(appb:EGFP) appb EGFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    appb Contained in: [BAC] DKEY-192G7 (1) (order this)
    appb Encodes: [EST] fc43a03 (1)
    [cDNA] MGC:92771 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_152886 (1) 4066 nt
    Genomic GenBank:CR759841 (1) 94752 nt
    Select Tool
    Polypeptide UniProtKB:B0V0E5 (1) 751 aa
    Sequence Information (all 33)
    ORTHOLOGY for appb ( Chr: 9 )
    CITATIONS (53)