ZFIN ID: ZDB-GENE-000616-13
Gene Name: amyloid beta (A4) precursor protein a
Gene Symbol: appa    Nomenclature History

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Previous Names: app, im:7044540, wu:fj08a12, wu:fj34d10, wu:fk65e12 (1), zgc:85740

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have heparin binding activity; serine-type endopeptidase inhibitor activity; and transition metal ion binding activity. Involved in central nervous system development; convergent extension; and vasculature development. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Is expressed in several structures, including female organism; heart; male organism; nervous system; and pleuroperitoneal region. Orthologous to human APP (amyloid beta precursor protein).
Genome Resources: Alliance (1),  Gene:58083 (1),  Ensembl(GRCz11):ENSDARG00000104279 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
is22Gt Transgenic Insertion Intron 4 Unknown DNA
zko32a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko32b Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-appa 1
    MO1-appa N/A 3
    MO2-appa N/A 1
    MO3-appa N/A 1
    DISEASE ASSOCIATED WITH appa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Alzheimer's disease 1 Alliance Alzheimer disease 1, familial 104300
    APP-related cerebral amyloid angiopathy Alliance Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic variants 605714
    DISEASE ASSOCIATED WITH appa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function heparin binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR019744 Amyloidogenic glycoprotein, copper-binding domain conserved site
    Conserved_site IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
    Conserved_site IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    Domain IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    Domain IPR008154 Amyloidogenic glycoprotein, extracellular
    Domain IPR011178 Amyloidogenic glycoprotein, copper-binding
    Domain IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptide
    Domain IPR015849 Amyloidogenic glycoprotein, heparin-binding
    Domain IPR019543 Beta-amyloid precursor protein C-terminal
    Domain IPR024329 Amyloidogenic glycoprotein, E2 domain
    Family IPR008155 Amyloidogenic glycoprotein
    Family IPR028866 Amyloid-beta precursor protein
    Homologous_superfamily IPR011993 PH-like domain superfamily
    Homologous_superfamily IPR036176 E2 domain superfamily
    Homologous_superfamily IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamily
    Homologous_superfamily IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamily
    Homologous_superfamily IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
    Homologous_superfamily IPR037071 Amyloidogenic glycoprotein, amyloid-beta peptide superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA appa-203 (1)    Ensembl 4339
    appa-205 (1)    Ensembl 620
    ncRNA appa-003 (1)    Ensembl 796
    appa-004 (1)    Ensembl 768
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-app monoclonal IgG1 Mouse WB Millipore
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM appa No data available
    MARKER RELATIONSHIPS
    appa Contained in: [Fosmid] CH1073-282F19 (1)
    appa Contains: [SNP] rs3727476 (1)
    appa Encodes: [EST] fj08a12, fj34d10, fk65e12 (1), IMAGE:7044540
    [cDNA] MGC:85740
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131564 (1) 3511 nt
    Genomic GenBank:FP067437 (1) 18410 nt
    Polypeptide UniProtKB:A0A0R4IN41 (1) 738 aa
    Sequence Information (all 49)
    ORTHOLOGY for appa ( Chr: 1 )
    CITATIONS (44)