Gene

appa

ID
ZDB-GENE-000616-13
Name
amyloid beta (A4) precursor protein a
Symbol
appa Nomenclature History
Previous Names
  • app
  • im:7044540
  • wu:fj08a12
  • wu:fj34d10
  • wu:fk65e12 (1)
  • zgc:85740
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable heparin binding activity; serine-type endopeptidase inhibitor activity; and transition metal ion binding activity. Acts upstream of or within central nervous system development; convergent extension; and vasculature development. Predicted to be located in Golgi-associated vesicle and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; nervous system; pleuroperitoneal region; segmental plate; and solid lens vesicle. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With appa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alzheimer's disease 1 Alliance Alzheimer disease 1, familial 104300
APP-related cerebral amyloid angiopathy Alliance Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic variants 605714
Associated With appa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019744 Amyloidogenic glycoprotein, copper-binding domain conserved site
Conserved_site IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
Conserved_site IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
Domain IPR002223 Pancreatic trypsin inhibitor Kunitz domain
Domain IPR008154 Amyloidogenic glycoprotein, extracellular
Domain IPR011178 Amyloidogenic glycoprotein, copper-binding
Domain IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptide
Domain IPR015849 Amyloidogenic glycoprotein, heparin-binding
Domain IPR019543 Beta-amyloid precursor protein C-terminal
Domain IPR024329 Amyloidogenic glycoprotein, E2 domain
Family IPR008155 Amyloidogenic glycoprotein
Family IPR028866 Amyloid-beta precursor protein
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR036176 E2 domain superfamily
Homologous_superfamily IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamily
Homologous_superfamily IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamily
Homologous_superfamily IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
Homologous_superfamily IPR037071 Amyloidogenic glycoprotein, amyloid-beta peptide superfamily
Domain Details Per Protein
Protein Length Amyloid-beta precursor protein Amyloidogenic glycoprotein Amyloidogenic glycoprotein, amyloid-beta peptide Amyloidogenic glycoprotein, amyloid-beta peptide superfamily Amyloidogenic glycoprotein, copper-binding Amyloidogenic glycoprotein, copper-binding domain conserved site Amyloidogenic glycoprotein, copper-binding domain superfamily Amyloidogenic glycoprotein, E2 domain Amyloidogenic glycoprotein, extracellular Amyloidogenic glycoprotein, heparin-binding Amyloidogenic glycoprotein, heparin-binding domain superfamily Amyloidogenic glycoprotein, intracellular domain, conserved site Beta-amyloid precursor protein C-terminal E2 domain superfamily Pancreatic trypsin inhibitor Kunitz domain Pancreatic trypsin inhibitor Kunitz domain superfamily PH-like domain superfamily Proteinase inhibitor I2, Kunitz, conserved site
UniProtKB:Q8UUS0 472
UniProtKB:A0A0R4IAB7 194
UniProtKB:A0A0R4IZ16 682
UniProtKB:Q9I9E7 612
UniProtKB:A0A0R4IN41 738
UniProtKB:A0A0R4IM64 207
UniProtKB:Q6NUZ1 738
UniProtKB:I6ZM20 682
UniProtKB:Q90W28 738
UniProtKB:Q8UUI8 357
UniProtKB:B0CM15 601
UniProtKB:Q7ZZT1 678
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-app monoclonal IgG1 Mouse
  • WB
Millipore
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations