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General Information
ZIRC
ZFIN ID: ZDB-GENE-000616-13
Gene Name: amyloid beta (A4) precursor protein a
Gene Symbol: appa
Sequence Ontology ID : SO:0000704

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Previous Names: app, im:7044540, wu:fj08a12, wu:fj34d10, wu:fk65e12 (1), zgc:85740

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(Including Attributions)
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have heparin binding activity; serine-type endopeptidase inhibitor activity; and transition metal ion binding activity. Involved in central nervous system development; convergent  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
is22Gt Transgenic Insertion Intron 4 Unknown DNA
zko32a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko32b Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH appa HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Alzheimer's disease 1 Alzheimer disease 1, familial 104300
    APP-related cerebral amyloid angiopathy Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic variants 605714
    DISEASE ASSOCIATED WITH appa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function heparin binding (more)
    GO Terms (all 9)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA appa-003 (1) 796
    appa-004 (1) 768
    mRNA appa-203 (1) 4339
    appa-205 (1) 620
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM appa No data available
    MARKER RELATIONSHIPS
    appaContained in: [Fosmid] CH1073-282F19 (1) (order this)
    appaContains: [SNP] rs3727476 (1)
    appaEncodes: [EST] fj08a12, fj34d10, fk65e12 (1), IMAGE:7044540
    [cDNA] MGC:85740 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131564 (1) 3511bp
    Genomic GenBank:FP067437 (1) 18410bp
    Polypeptide UniProtKB:A0A0R4IN41 (1) 738aa
    Sequence Clusters UniGene:105653 (1)
    Sequence Information (all 53)
    ORTHOLOGY for appa (Chr: 1)
    CITATIONS (42)