ZFIN ID: ZDB-GENE-020122-1
Gene Name: Meis homeobox 1 b
Gene Symbol: meis1b    Nomenclature History

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Previous Names: meis1.1 (1), meis1, cb224 (1), etID37540.13 (1), id:ibd5078 (1), wu:fb38b03 (1), wu:fc02e11 (1), wu:fd12a02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA binding activity. Involved in several processes, including animal organ development; blood vessel morphogenesis; and protein stabilization. Predicted to localize to the nucleus. Is expressed in several structures, including anterior neural keel; hindbrain neural keel; immature eye; nervous system; and neural rod. Orthologous to human MEIS1 (Meis homeobox 1).
Genome Resources: Alliance (1),  Gene:170446 (1),  Ensembl(GRCz11):ENSDARG00000012078 (2)
GENE EXPRESSION
All Expression Data: 35 figures from 16 publications
Directly Submitted Expression Data: 6 figures (25 images) from Thisse et al., 2001 [cb224]
  4 figures (4 images) from Kudoh et al., 2001 [ibd5078]
  6 figures (26 images) from Thisse et al., 2005 [eu422]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011357Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012440Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9839 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19051 Point Mutation Unknown Premature Stop ENU
    sa35409 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-meis1 N/A 1
    MO1-meis1b N/A 7
    MO2-meis1 N/A 2
    MO2-meis1b N/A 2
    MO3-meis1b N/A 1
    MO5-meis1b N/A 1
    MO6-meis1b N/A 1
    DISEASE ASSOCIATED WITH meis1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH meis1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of angiogenesis (more)
    Cellular Component cytosol (more)
    Molecular Function protein binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001356 Homeobox domain
    Domain IPR008422 Homeobox KN domain
    Domain IPR032453 Homeobox protein PKNOX/Meis, N-terminal
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA meis1b-201 (1)    Ensembl 2644
    ncRNA meis1b-002 (1)    Ensembl 893
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-meis1 monoclonal IgG Rabbit IHC Abcam plc
    Epitomics, Inc
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM meis1b No data available
    MARKER RELATIONSHIPS
    meis1b Contained in: [BAC] DKEY-196J8 (1) (order this), DKEY-205F16 (1) (order this)
    meis1b Encodes: [EST] cb224 (1) (order this), eu422 (1), fb38b03 (1), fc02e11 (1), fd12a02, ibd5078 (1)
    [cDNA] MGC:73029 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131893 (1) 2269 nt
    Genomic GenBank:BX276188 (1) 177660 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QIZ3 (1) 463 aa
    Sequence Information (all 23)
    ORTHOLOGY for meis1b ( Chr: 13 )
    CITATIONS (70)