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ZIRC
ZFIN ID: ZDB-GENE-020117-2
Gene Name: gastrulation brain homeobox 1
Gene Symbol: gbx1    Nomenclature History

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Previous Names: cb619 (1), fj77a06, wu:fj77a06 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in cerebellum development; midbrain-hindbrain boundary morphogenesis; and regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation. Predicted to localize to the nucleus. Is expressed in several structures, including nervous system; neural keel; neural plate; presumptive neural plate; and ventral mesoderm. Orthologous to human GBX1 (gastrulation brain homeobox 1).
Genome Resources: Alliance (1),  Gene:142985 (1),  Ensembl(GRCz11):ENSDARG00000071418 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh271 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • gbx1_unrecovered Point Mutation Unknown Unknown ENU
    um300 Insertion Unknown Unknown CRISPR
    um301 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gbx1 1
    MO1-gbx1 N/A 1
    MO2-gbx1 N/A 1
    DISEASE ASSOCIATED WITH gbx1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH gbx1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cerebellum development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gbx1-201 (1)    Ensembl 1824
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gbx1 No data available
    MARKER RELATIONSHIPS
    gbx1 Contained in: [BAC] CH211-89L23 (1) (order this)
    gbx1 Encodes: [EST] cb619 (1) (order this), fj77a06 (1), mb1 (1)
    [cDNA] MGC:194383 (1) (order this), MGC:194384 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_174861 (1) 1837 bp
    Genomic GenBank:CT583690 (1) 177248 bp
    Select Tool
    Polypeptide UniProtKB:Q90ZB2 (1) 316 aa
    Sequence Clusters UniGene:81466 (1)
    Sequence Information (all 21)
    ORTHOLOGY for gbx1 ( Chr: 24 )
    CITATIONS (58)