Gene

cxcr4a

ID
ZDB-GENE-020102-1
Name
chemokine (C-X-C motif) receptor 4a
Symbol
cxcr4a Nomenclature History
Previous Names
  • cb824 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including ameboidal-type cell migration; embryonic viscerocranium morphogenesis; and vasculature development. Predicted to localize to external side of plasma membrane. Is expressed in several structures, including brain; endoderm; mesoderm; tail bud; and vasculature. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
Genome Resources
Note
None
Expression
All Expression Data
55 figures from 35 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
32 figures from 15 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cxcr4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
WHIM syndrome Alliance WHIM syndrome 193670
Myelokathexis, isolated
Associated With cxcr4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000355 Chemokine receptor family
Family IPR001277 CXC chemokine receptor 4/atypical chemokine receptor 2
Domain Details Per Protein
Protein Length Chemokine receptor family CXC chemokine receptor 4/atypical chemokine receptor 2 GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:Q8UUW8 360
UniProtKB:F8W4X7 283
UniProtKB:Q7ZU02 360
UniProtKB:F1QCB2 360
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations