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ZIRC
ZFIN ID: ZDB-GENE-011219-1
Gene Name: cytochrome P450, family 1, subfamily A
Gene Symbol: cyp1a    Nomenclature History

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Previous Names: cyp1a1 (1), zfCYP1A, wu:fb63b04 (1), zgc:109747

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have monooxygenase activity. Involved in cellular aromatic compound metabolic process; cellular response to organic cyclic compound; and cellular response to xenobiotic stimulus. Predicted to localize to the intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); bone inflammation disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Is expressed in several structures, including digestive system; pectoral fin bud; pericardial region; tail bud; and vasculature. Orthologous to several human genes including CYP1A1 (cytochrome P450 family 1 subfamily A member 1).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000098315 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027978Tg Transgenic Insertion Unknown Unknown DNA
sa17179 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cyp1a
    1
    CRISPR2-cyp1a
    1
    CRISPR3-cyp1a
    1
    CRISPR4-cyp1a
    1
    CRISPR5-cyp1a
    1
    MO1-cyp1a N/A 13
    MO2-cyp1a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular aromatic compound metabolic process (more)
    Cellular Component intracellular membrane-bounded organelle (more)
    Molecular Function heme binding (more)
    GO Terms (all 13)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp1a-201 (1)    Ensembl 2608
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cyp1a monoclonal IgG3 , k Mouse IHC Cayman Chemical Company
    Biosense Laboratories
    9
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(cyp1a-6xdire:egfp) cyp1aDIRE EGFP Danio rerio 1 1
    tg(cyp1a-12xdire:egfp) cyp1aDIRE EGFP Danio rerio 1 1
    Tg(cyp1a:mCherry) cyp1a mCherry Danio rerio 3 1
    Tg2(cyp1a:mCherry) cyp1a mCherry Danio rerio 1 1
    TgBAC(cyp1a:NLS-EGFP) cyp1a EGFPNLS Danio rerio 1 5
    MARKER RELATIONSHIPS
    cyp1a Contained in: [Fosmid] CH1073-392K22 (1) (order this)
    cyp1a Encodes: [EST] fb63b04 (1), IMAGE:7163229 (1) (order this)
    [cDNA] MGC:109747 (1) (order this), MGC:193050 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:BC094977 (1) 2622 bp
    Genomic GenBank:CU462829 (1) 31938 bp
    Select Tool
    Polypeptide UniProtKB:Q6TH23 (1) 519 aa
    Sequence Information (all 16)
    ORTHOLOGY for cyp1a ( Chr: 18 )
    CITATIONS (289)