ZFIN ID: ZDB-GENE-011212-6
Gene Name: transcription factor AP-2 alpha
Gene Symbol: tfap2a
Sequence Ontology ID : SO:0000704

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Previous Names: ap2 (1), ap2a (1), cb93 (1), fb83f04, fc31a07 (1), lockjaw, low, mob (1), mont blanc (1), wu:fb83f04 (1), wu:fc31a07 (1)

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(Including Attributions)
Location: Chr: 24 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 59 figures from 41 publications
Directly Submitted Expression Data: 6 figures (19 images) from Thisse et al., 2001 [cb93]
  6 figures (24 images) from Rauch et al., 2003 [fb83f04]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  basal plate midbrain region, brain, cerebellum, cornea (all 50) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m610 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m780 Point Mutation Unknown Unknown ENU
    m819 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24445 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tfap2a_unspecified Unspecified Unknown Unknown
    ts213 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-tfap2a (1), MO2-tfap2a (1), MO3-tfap2a (1), MO4-tfap2a (1)
    PHENOTYPE
    Data: 30 figures from 12 publications
    Observed in: anterior catecholaminergic tract, autonomic nervous system development, basihyal cartilage, brain (all 57) expand
    DISEASE ASSOCIATED WITH tfap2a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    branchiooculofacial syndrome Branchiooculofacial syndrome 113620
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function transcription factor activity, sequence-specific DNA binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004979
  • InterPro:IPR008121
  • InterPro:IPR013854
  • Pfam:PF03299
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-tfap2a (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tfap2a
    Tg(hsp70l:tfap2a)
    MARKER RELATIONSHIPS
    tfap2aContains: [SNP] rs3729319 (1), rs3729320 (1), rs3729321 (1)
    tfap2aEncodes: [EST] cb93 (1) (order this), fb83f04 (1) (order this), fc31a07 (1)
    [cDNA] MGC:73067 (1) (order this), MGC:76915 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001319159 (1) 2860bp
    Genomic GenBank:LO018137 (1)
    Polypeptide UniProtKB:F1QUT4 437aa
    Sequence Clusters UniGene:8506 (1)
    Sequence Information (all 39)
    OTHER tfap2a GENE PAGES
  • Gene:140618 (1)
  • Ensembl(GRCz10):ENSDARG00000059279 (1)
  • ORTHOLOGY for tfap2a (Chr: 24)
    CITATIONS (110)