Gene

mafa

ID
ZDB-GENE-010605-2
Name
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
Symbol
mafa Nomenclature History
Previous Names
  • c-Maf (1)
  • maf
  • fl13d12
  • wu:fl13d12 (1)
  • Z-cmaf (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Is expressed in pronephric mesoderm; pronephric proximal convoluted tubule; pronephric proximal straight tubule; and solid lens vesicle. Orthologous to human MAF (MAF bZIP transcription factor).
Genome Resources
Note
This gene, the ortholog and one of the zebrafish genome duplicates of the human MAF gene, has the same gene symbol as a different human gene (MAFA). This zebrafish mafa gene is not the ortholog of human MAFA. The identical gene symbol for non-orthologous genes is due to the genome duplicate naming conventions of the zebrafish nomenclature guidelines. The zebrafish ortholog of the human MAFA gene is mafaa (ZDB-GENE-010605-3).
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mafa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ayme-Gripp syndrome Alliance Ayme-Gripp syndrome 601088
cataract 21 multiple types Alliance Cataract 21, multiple types 610202
Associated With mafa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004826 Basic leucine zipper domain, Maf-type
Domain IPR004827 Basic-leucine zipper domain
Domain IPR013592 Maf transcription factor, N-terminal
Family IPR024874 Transcription factor Maf family
Family IPR028573 Transcription factor Maf
Homologous_superfamily IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Basic-leucine zipper domain Basic leucine zipper domain, Maf-type Maf transcription factor, N-terminal Transcription factor Maf Transcription factor Maf family Transcription factor, Skn-1-like, DNA-binding domain superfamily
UniProtKB:A0A286Y8Q5 333
UniProtKB:Q6NZW9 325
UniProtKB:Q9W6B1 324
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations