ZFIN ID: ZDB-GENE-010605-2
Gene Name: v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
Gene Symbol: mafa    Nomenclature History

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Previous Names: c-Maf (1), maf, fl13d12, wu:fl13d12 (1), Z-cmaf (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Is expressed in pronephric mesoderm; pronephric proximal convoluted tubule; pronephric proximal straight tubule; and solid lens vesicle. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Orthologous to human MAF (MAF bZIP transcription factor).
Genome Resources: Alliance (1),  Gene:114467 (1),  Ensembl(GRCz11):ENSDARG00000015890 (2)
Note: This gene, the ortholog and one of the zebrafish genome duplicates of the human MAF gene, has the same gene symbol as a different human gene (MAFA). This zebrafish mafa gene is not the ortholog of human MAFA. The identical gene symbol for non-orthologous genes is due to the genome duplicate naming conventions of the zebrafish nomenclature guidelines. The zebrafish ortholog of the human MAFA gene is mafaa (ZDB-GENE-010605-3).
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mafa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ayme-Gripp syndrome Alliance Ayme-Gripp syndrome 601088
cataract 21 multiple types Alliance Cataract 21, multiple types 610202
DISEASE ASSOCIATED WITH mafa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription, DNA-templated (more)
Cellular Component host cell nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mafa-201 (1)    Ensembl 3023
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mafa No data available
MARKER RELATIONSHIPS
mafa Contained in: [BAC] CH73-271P22 (1)
mafa Encodes: [cDNA] MGC:76816 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131844 (1) 2847 nt
Genomic GenBank:CR388185 (1) 178361 nt
Select Tool
Polypeptide UniProtKB:A0A286Y8Q5 (1) 333 aa
Sequence Information (all 20)
ORTHOLOGY for mafa ( Chr: 18 )
CITATIONS (33)