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ZIRC
ZFIN ID: ZDB-GENE-010126-2
Gene Name: neurotrophic tyrosine kinase, receptor, type 2b
Gene Symbol: ntrk2b    Nomenclature History

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Previous Names: trkB2 (1), si:ch211-220b11.1, si:ch73-270f14.4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Involved in neuromast primordium migration. Predicted to localize to the axon; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; early infantile epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Is expressed in gut and nervous system. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
Genome Resources: Alliance (1),  Gene:570240 (1),  Ensembl(GRCz11):ENSDARG00000098511 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015737Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39 Point Mutation Unknown Premature Stop ENU
    sa8981 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13660 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17691 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17771 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ntrk2b N/A 1
    MO2-ntrk2b N/A 1
    MO3-ntrk2b N/A 1
    DISEASE ASSOCIATED WITH ntrk2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 58 Alliance Epileptic encephalopathy, early infantile, 58 617830
    Obesity, hyperphagia, and developmental delay 613886
    DISEASE ASSOCIATED WITH ntrk2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lateral line development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 29)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ntrk2b-201 (1)    Ensembl 2616
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ntrk2 polyclonal Rabbit IHC, WB Santa Cruz Biotechnology, Inc.
    10
    Ab1-ntrk polyclonal Rabbit WB Santa Cruz Biotechnology, Inc.
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ntrk2b No data available
    MARKER RELATIONSHIPS
    ntrk2b Contained in: [BAC] CH73-270F14 (1) (order this), DKEY-20J10 (1) (order this)
    ntrk2b Contains: [STS] zfishb-a2453g04.p1c (1)
    ntrk2b Encodes: [EST] cssl:d0314 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001197161 (1) 2563 bp
    Genomic GenBank:BX323563 (1) 97393 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4ITX7 (1) 801 aa
    Sequence Clusters UniGene:122048 (1)
    Sequence Information (all 13)
    ORTHOLOGY for ntrk2b ( Chr: 5 )
    CITATIONS (39)