Gene

ntrk2b

ID
ZDB-GENE-010126-2
Name
neurotrophic tyrosine kinase, receptor, type 2b
Symbol
ntrk2b Nomenclature History
Previous Names
  • trkB2 (1)
  • si:ch211-220b11.1
  • si:ch73-270f14.4
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Involved in neuromast primordium migration. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Is expressed in gut and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; early infantile epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
Genome Resources
Note
None
Expression
All Expression Data
16 figures from 7 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ntrk2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early infantile epileptic encephalopathy 58 Alliance Epileptic encephalopathy, early infantile, 58 617830
Obesity, hyperphagia, and developmental delay 613886
Associated With ntrk2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2
Family IPR020777 Tyrosine-protein kinase, neurotrophic receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Repeat IPR001611 Leucine-rich repeat
Domain Details Per Protein
Protein Length Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Leucine-rich repeat Leucine-rich repeat domain superfamily Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, neurotrophic receptor Tyrosine-protein kinase, neurotrophic receptor, type 2 Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:A8BAT8 401
UniProtKB:A0A0R4ILA2 799
UniProtKB:A0A0R4ITX7 801
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ntrk2 polyclonal Rabbit
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
10
Ab1-ntrk polyclonal Rabbit
  • WB
Santa Cruz Biotechnology, Inc.
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations