PUBLICATION

Five Trk receptors in the zebrafish

Authors
Martin, S.C., Marazzi, G., Sandell, J.H., and Heinrich, G.
ID
ZDB-PUB-961014-739
Date
1995
Source
Developmental Biology   169: 745-758 (Journal)
Registered Authors
Heinrich, Gerhard, Martin, Stella C., Sandell, Julie H.
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Southern
  • Brain/embryology
  • Brain/metabolism
  • Cloning, Molecular
  • DNA, Complementary
  • Fertilization
  • Gene Expression Regulation, Developmental
  • Molecular Sequence Data
  • Precipitin Tests
  • RNA, Messenger/genetics
  • RNA, Messenger/metabolism
  • Receptors, Nerve Growth Factor/chemistry
  • Receptors, Nerve Growth Factor/genetics*
  • Sequence Homology, Amino Acid
  • Zebrafish/embryology
  • Zebrafish/genetics*
PubMed
7781913 Full text @ Dev. Biol.
Abstract
Using a homology-based cloning strategy we have identified five members of the Trk family in the zebrafish Danio rerio. They are homologous to the three mammalian Trk receptors in their conserved intracellular kinase regions and the organization of their extracellular regions. The five trk genes are differentially expressed in the developing brain, spinal cord, cranial ganglia, and retina. Full-length forms of three of the trk genes are expressed when neurons pioneer the major axon tracts, whereas the two other trk genes have a later onset of expression. Truncated transcripts and forms containing an extracellular juxtamembrane region insert were found. The degree of sequence variation and expression differences within the family suggest that each of the five zebrafish Trk receptors have a functionally distinct role. These findings demonstrate that the vertebrate Trk family is larger than previously appreciated.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes