ZFIN ID: ZDB-GENE-001031-1
Gene Name: paired box 6b
Gene Symbol: pax6b
Previous Names: Pax6.2, cb566 (1), fc09c10, id:ibd5095 (1), sri(l), wu:fc09c10 (1), wu:fc33g08
Location: Chr: 7   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 67 figures from 44 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2001 [cb566]
  6 figures (36 images) from Thisse et al., 2004 [MGC:92546]
  3 figures (4 images) from Kudoh et al., 2001 [ibd5095]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  amacrine cell, anterior neural plate, axis, brain (all 48) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 7 Genotypes
Knockdown reagents: MO1-pax6b (1), MO2-pax6b (1), MO3-pax6b (1), MO4-pax6b (1), MO5-pax6b (1) (all 8) expand

Allele Type Mutagen Suppliers
la010682Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029282Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa86 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9552 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa11497 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  •    expand Show all 8 alleles
    PHENOTYPE
    Data: 14 figures from 7 publications
    Observed in: anatomical system, anterior/posterior pattern specification, cornea, D cell (all 17) expand

    Phenotype of Human Orthologue OMIM Phenotype ID
    Aniridia 106210
    Cataract with late-onset corneal dystrophy 106210
    Coloboma of optic nerve 120430
    Coloboma, ocular 120200
    Foveal hypoplasia 1 136520
    Gillespie syndrome 206700
    Keratitis 148190
    Optic nerve hypoplasia 165550
    Peters anomaly 604229
    ?Morning glory disc anomaly 120430
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription from RNA polymerase II promoter (more)
    Cellular Component nucleus (more)
    Molecular Function sequence-specific DNA binding RNA polymerase II transcription factor activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR001523 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR011991 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS00034 (1)
  • PROSITE:PS50071 (1)
  • PROSITE:PS51057 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF00292 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pax6b-001 (1) 4993
    ncRNA pax6b-002 (1) 1598
    mRNA pax6b-003 (1) 557
    pax6b-004 (1) 394
    pax6b-005 (1) 578
    ncRNA pax6b-006 (1) 683
    pax6b-007 (1) 681
    pax6b-008 (1) 830
    mRNA pax6b-009 (1) 571
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab2-pax6 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pax6b
    Tg(pax6a-gata2:mCherry,pax6b-gata2:GFP), Tg(pax6b-gata2a:EGFP), Tg(pax6b:DsRed), Tg(pax6b:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pax6b Contained in: [BAC] DKEY-157G7 (1) (order this)
    pax6b Contains: [SNP] rs3728027 (1), rs3728028 (1)
    pax6b Encodes: [EST] cb566 (1) (order this), fc09c10, fc33g08, ibd5095 (order this)
    [cDNA] MGC:92546 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131641 (1) 1733 bp
    Genomic GenBank:BX000453 (1) 163585 bp
    Select Tool
    Polypeptide UniProtKB:Q9YHZ8 (1) 437 aa
    Sequence Clusters UniGene:132861 (1)
    Sequence Information (all 38)
    OTHER pax6b GENE PAGES
  • Gene:60639 (1)
  • VEGA:OTTDARG00000018846 (1)
  • Ensembl(Zv9):ENSDARG00000045936 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish pax6b 7  
    Human PAX6 11 (11p13)
  • OMIM:607108
  • Gene:5080
  • Mouse Pax6 2 ( 55.31 cM)
  • MGI:97490
  • Gene:18508
  • Orthology Details
    CITATIONS (99)