ZFIN ID: ZDB-GENE-001031-1
Gene Name: paired box 6b
Gene Symbol: pax6b
Previous Names: Pax6.2, cb566 (1), fc09c10, id:ibd5095 (1), sri(l), wu:fc09c10 (1), wu:fc33g08
Location: Chr: 7 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 73 figures from 47 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2001 [cb566]
  6 figures (36 images) from Thisse et al., 2004 [MGC:92546]
  3 figures (4 images) from Kudoh et al., 2001 [ibd5095]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  amacrine cell, anterior neural plate, anterior segment eye, axis (all 54) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
la010682Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029282Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa86 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9552 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa11497 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa13392 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15822 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • tq253a Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-pax6b (1), MO2-pax6b (1), MO3-pax6b (1), MO4-pax6b (1), MO5-pax6b (1) (all 8) expand
    PHENOTYPE
    Data: 15 figures from 8 publications
    Observed in: anatomical system, anterior segment eye mesenchymal cell, anterior segment eye, anterior/posterior pattern specification (all 20) expand
    DISEASE ASSOCIATED WITH pax6b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    aniridia Aniridia 106210
    Cataract with late-onset corneal dystrophy 106210
    coloboma Coloboma, ocular 120200
    coloboma of optic nerve Coloboma of optic nerve 120430
    ?Morning glory disc anomaly 120430
    Optic nerve hypoplasia 165550
    Gillespie syndrome 206700
    Peters anomaly 604229
    Foveal hypoplasia 1 136520
    Keratitis 148190
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription from RNA polymerase II promoter (more)
    Cellular Component nucleus (more)
    Molecular Function RNA polymerase II transcription factor activity, sequence-specific DNA binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR001523 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR011991 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS00034 (1)
  • PROSITE:PS50071 (1)
  • PROSITE:PS51057 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF00292 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pax6b-001 (1) 4993
    ncRNA pax6b-002 (1) 1598
    mRNA pax6b-003 (1) 557
    pax6b-004 (1) 394
    pax6b-005 (1) 578
    ncRNA pax6b-006 (1) 683
    pax6b-007 (1) 681
    pax6b-008 (1) 830
    mRNA pax6b-009 (1) 571
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab2-pax6 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pax6b
    Tg(pax6a-gata2:mCherry,pax6b-gata2:GFP), Tg(pax6b-gata2a:EGFP), Tg(pax6b:DsRed), Tg(pax6b:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pax6bContained in: [BAC] DKEY-157G7 (1) (order this)
    pax6bContains: [SNP] rs3728027 (1), rs3728028 (1)
    pax6bEncodes: [EST] cb566 (1) (order this), fc09c10, fc33g08, ibd5095 (order this)
    [cDNA] MGC:92546 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131641 (1) 1733bp
    Genomic GenBank:BX000453 (1) 163585bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IQL7 (1) 450aa
    Sequence Clusters UniGene:132861 (1)
    Sequence Information (all 41)
    OTHER pax6b GENE PAGES
  • Gene:60639 (1)
  • VEGA:OTTDARG00000018846 (1)
  • Ensembl(GRCz10):ENSDARG00000045936 (1)
  • ORTHOLOGY for pax6b (Chr: 7)
    Species Symbol Chromosome Accession # Evidence
    Human PAX6 11
  • Gene:5080
  • OMIM:607108
  • HGNC:8620
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (3)
    Mouse Pax6 2
  • MGI:97490
  • Gene:18508
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (103)