FIGURE

Fig. 3

ID

ZDB-FIG-240422-26

Publication

Pontius et al., 2024 - Magnetically powered microwheel thrombolysis of occlusive thrombi in zebrafish

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Fig. 3

tPA-functionalized µwheels are necessary for recanalization. The PCV of 3 dpf larvae was injured, producing completely occlusive thrombi, followed by no infusion (n = 18), the infusion of microparticles functionalized with ~8.4 pg of tPA (n = 16), unfunctionalized µwheels (n = 15), or tPA-functionalized µwheels carrying ~8.4 pg of tPA (n = 15). The field was applied in rolling mode either until recanalization was observed or a maximum of 30 min. Beyond that point, the coils became too hot and damaged the larvae. Larvae infused with tPA-functionalized µwheels recanalized within 11.8 ± 5.4 min while those infused with non-functionalized µwheels, tPA-functionalized particles without the application of a magnetic field, and uninfused larvae continued to be occluded after 30 min (P < 0.0001 by Mantel-Cox log-rank testing). Bars represent median recanalization time.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA