Fig. 3

Distinct chromatin accessibility profiles in the developing and regenerating epicardia (A) Differential peak accessibility analysis, comparing tcf21 larval epi with tcf21 cryo. Shown are log2-transformed accessibility fold changes and Benjamini-Hochberg-adjusted Wald test p values. Significantly enriched peaks (adjusted p value < 0.05) are colored in red. Highlighted are peaks located in the tcf21 locus. (B) Chromatin accessibility in the tcf21 locus. Peaks significantly enriched in cryoinjured versus larval epicardium are highlighted in red. (C) Relative quantification of differentially accessible peak distribution across genomic features. (D) GO term over-representation of genes located close to peaks enriched in tcf21 larval epi (left column) or tcf21 cryo (right column). Bubble size depicts the magnitude of statistical enrichment, color significance. (E) Differential accessibility of peaks located in the vicinity of marker genes of larval and adult cryoinjured epicardium (n = 52), quantified on gene level. Bubble color indicates the ratio of the number of differentially accessible peaks enriched in tcf21 larval epi versus the number of peaks enriched in tcf21 cryo (green = all tcf21 larval epi, brown = all tcf21 cryo, white = equal ratio).