FIGURE
Fig. 2
- ID
- ZDB-FIG-230906-20
- Publication
- Jing et al., 2023 - Synthetic lethal targeting of TET2-mutant haematopoietic stem and progenitor cells by XPO1 inhibitors
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Fig. 2
Selinexor and eltanexor treatment do not affect the birth of haematopoietic stem and progenitor cells (HSPCs) from the aorta-gonad-mesonephros (AGM) region. (A) Embryos with the indicated genotypes were treated with either dimethylsulfoxide (DMSO), selinexor (100 nM) or eltanexor (250 nM) dissolved in fish water from 1 to 2 days post fertilisation (dpf). Whole-mount in situ hybridisation was performed using a riboprobe for c-myb at 2 dpf and images were taken (overall magnification: 5×). Insets in each of the image magnify staining in the AGM region (magnification in the inset: 11.25×). (B) Quantification of cells with c-myb expression in the AGM region, as shown in panel A.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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Full text @ Br. J. Haematol.