FIGURE

Fig. 8

ID

ZDB-FIG-230712-15

Publication

Siddiqui et al., 2023 - Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease

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Fig. 8

Schematic view of the NGFR/LCN2/SLC22A17-dependent neurogenic switch mechanism in astroglia.

Nerve growth factor receptor can convert reactive astroglia to neurogenic state in mouse model of Alzheimer’s disease (AD) through suppression of Lcn2 activity on Slc22a17 receptor. In AD cohorts in humans, NGFR is co-expressed with a weighed expression cluster including PFKP, blockage of which enhances neurogenesis from astroglia. In zebrafish, Ngfr activity determines the neuroregenerative potential after amyloid toxicity. We propose an evolutionarily conserved mechanism relating to neurogenesis-related brain resilience in vertebrates.

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Acknowledgments

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