Figure 5—figure supplement 3.

Expression of TP53P153Δ with kRASG12D in tp53-/- zebrafish results in the initiation of medulloblastomas with a shh gene signature. (TP53P153Δ).

(A) Representative images of tp53-/- fish with head embryonal rhabdomyosarcoma (ERMS) tumors, expressing TP53P153Δ (DsRED positive). The zebrafish in (A) are between 25 and 50 d. Scale bar = 1 mm. (B) H&E of the head regions of tp53-/- fish with head ERMS tumors, expressing TP53P153Δ. (C) H&E stained sections at ×20 magnification of tp53-/- fish with head ERMS tumors, expressing TP53P153Δ. (D) IHC for myosin heavy chain at ×20 magnification of tp53-/- fish with head ERMS tumors, expressing TP53P153Δ. Scale bar = 100 µm.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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