FIGURE

Fig. 1

ID

ZDB-FIG-230508-92

Publication

Lasbleiz et al., 2022 - Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling

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Fig. 1

S1R activation rescued touch-escape response of TDP43^G348C-expressing zebrafish larvae. (A) Touch-escape response of control larvae or larvae expressing mCherry alone or with TDP43^G348C. Swimming distance in 5 s was measured after tactile stimulation of 5 days post-fertilization (dpf) larvae. (B) Touch-escape response of control larvae or larvae expressing TDP43^G348C, TDP43^G348C + S1R or S1R alone. (C) Touch-escape response of control larvae, larvae expressing TDP43^G348C alone or treated with 5 or 10 μM of PRE-084. (D) Touch-escape response of control larvae or larvae expressing TDP43^G348C alone, treated with PRE-084 (5 μM) or treated with PRE-084 and NE-100 (5 μM each). (E) Touch-escape response of control, TDP43^G348C larvae treated or not with SA4503 (5 μM). In all figures data from 20 were averaged and presented as mean ± SEM. Statistical analysis was performed using ANOVA followed by Tukey's test (*p < 0.05; **p < 0.01; ***p < 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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