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Fig. 1

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ZDB-FIG-230312-29

Publication

Nam et al., 2022 - The Novel Human HtrA2 Ortholog in Zebrafish: New Molecular Insight and Challenges into the Imbalance of Homeostasis

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Fig. 1

Fig. 1. High structural homology between the zebrafish LOC561604 (zHtrA2) and zHtrA2 protein and the human counterparts. (A) The shared synteny between the chromosomal regions containing the human and zebrafish HtrA2. hHtrA2 and zHtrA2 (red box) are in the order of NAT8 and DCTN1 on the human chromosome (Chr) 2 and nat8 and dctn1b on zebrafish Chr 13, respectively. The orthologous counterparts of the two species are connected by gray lines. (B) A schematic diagram of the LOC561604 gene. Splicing eliminates the introns and joins eight exons (black box) to produce the mRNA. The FLAG epitope tag (yellow box) was cloned into the C-terminus of the plasmid encoding zHtrA2 (AA 1–436). (C) The alignment and the conservation between the amino acid (AA) sequence of HtrA2 proteins. The pairwise alignment of two sequences was performed with the Clustal W program and BoxShade Sever from EMBnet. Black and gray boxes indicate the identical and conservatively altered AAs, respectively. Hs, Homo sapiens and Dr, Danio rerio.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Gene, 819, Nam, M.K., Moon, J.M., Kim, G.Y., Min Kim, S., Rhim, H., The Novel Human HtrA2 Ortholog in Zebrafish: New Molecular Insight and Challenges into the Imbalance of Homeostasis, 146263, Copyright (2022) with permission from Elsevier. Full text @ Gene