FIGURE

Figure 5

ID

ZDB-FIG-230305-16

Publication

Liu et al., 2023 - Enhanced insulin activity achieved in VDRa/b ablation zebrafish

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Figure 5

Glucose metabolic homeostasis was impaired in the liver of vdra^-/- ;vdrb^-/- zebrafish. (A) Blood glucose levels of vdra^-/-;vdrb^-/- fish and control siblings in the fasted state and postprandial state at 100 dpf. (B–D). Quantitative real-time PCR showed glut2, gck and chrebp transcriptional levels in the liver of mutants and control siblings at 100 dpf; (E) Quantitative real-time PCR showed gluconeogenesis marker gene g6pca.1, g6pca.2 and pck1 transcriptional levels in the liver of the vdra ^-/-;vdrb^-/- fish and control siblings at 100dpf. (F) The liver glycogen levels in vdra ^-/-;vdrb ^-/- fish and control siblings at 100 dpf. (G, H). The liver lactic acid levels in vdra ^-/-;vdrb ^-/- fish and control siblings at 100 dpf. The bars with different letters indicated significant difference (p<0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)