FIGURE

Figure 3

ID

ZDB-FIG-230228-169

Publication

Sato et al., 2023 - Transgenic Zebrafish Expressing Rat Cytochrome P450 2E1 (CYP2E1): Augmentation of Acetaminophen-Induced Toxicity in the Liver and Retina

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Figure 3

Acetaminophen-induced reduction in the size of the retina in rat CYP2E1-TG larvae. EGFP fluorescence-negative (EGFP [−]) and -positive (EGFP [+]) F2 CYP2E1-transgenic larvae were exposed to 2.5 mM acetaminophen (APAP) from 24 hpf to 54 hpf for capture of lateral and dorsal images. (A,B,E,F): EGFP [−] larvae. (C,D,G,H): EGFP [+] larvae. (I) indicates quantitative data of lateral area of the retina in the bar graph (n = 10). The retina was circled by white interrupted line for quantification for example (C,D). Scale bar: 200 µm. Bars with different letters in (I), (a, b) are significantly different (p < 0.05). Mild pericardial edema was indicated by arrowhead in D.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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