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Fig. 5

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ZDB-FIG-230126-21

Publication

do Amaral et al., 2022 - The perinuclear region concentrates disordered proteins with predicted phase separation distributed in a 3D network of cytoskeletal filaments and organelles

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Fig. 5

Some proteins of the perinuclear region show the unusual chemical characteristics of IDPs. (A) The charge-hydropathy analysis of the human perinuclear proteins retrieved from the UniProt database (purple squares) and literature (green circles). Inset: globular folded proteins represented as blue circles and natively unfolded proteins as red dots. (B) Zoomed area marked by dashed line from “A”. (C) List of perinuclear proteins with the exquisite charge-hydropathy of IDPs, numbers refer to “B”. Plot described by [29] using 275 globular proteins (blue circles) and 91 IDPs (red circles) that enable differentiation (black line) by their charged and hydrophobic nature at pH 7.0 and obtained by PONDR (available at http://www.pondr.com/).

Expression Data

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Antibody Labeling

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Acknowledgments

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Reprinted from Biochimica et biophysica acta. Molecular cell research, 1869, do Amaral, M.J., de Andrade Rosa, I., Andrade, S.A., Fang, X., Andrade, L.R., Costa, M.L., Mermelstein, C., The perinuclear region concentrates disordered proteins with predicted phase separation distributed in a 3D network of cytoskeletal filaments and organelles, 119161, Copyright (2022) with permission from Elsevier. Full text @ BBA Molecular Cell Research